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World J Gastroenterol. Dec 7, 2013; 19(45): 8312-8320
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8312
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8312
Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome
Francesco Tonelli, Francesco Giudici, Gabriella Nesi, Giacomo Batignani, Maria Luisa Brandi, Surgical Unit, Department of Surgery and Translational Medicine, University of Florence, 50014 Florence, Italy
Author contributions: All authors contributed equally to this work; Tonelli F, Giudici F and Batignani G collected the data; Tonelli F, Giudici F, Nesi G, Batignani G and Brandi ML analyzed data and wrote the manuscript; Brandi ML supervised the study.
Correspondence to: Francesco Tonelli, MD, Surgery Unit, Department of Clinical Physiopathology, University of Florence, Largo Brambilla 3, 50014 Florence, Italy. francesco.tonelli@unifi.it
Telephone: +39-55-7947449 Fax: +39-55-7947449
Received: April 29, 2013
Revised: June 29, 2013
Accepted: July 4, 2013
Published online: December 7, 2013
Processing time: 232 Days and 11.5 Hours
Revised: June 29, 2013
Accepted: July 4, 2013
Published online: December 7, 2013
Processing time: 232 Days and 11.5 Hours
Core Tip
Core tip: Enteropancreatic endocrine neoplasms affect up to 90% of multiple endocrine neoplasia type1 (MEN1) patients. Gastrinomas are the most common functional enteropancreatic neuroendocrine tumors and were thought to be located almost exclusively in the duodenum in MEN1 patients. This study describes our experience regarding ectopic biliary tree gastrinomas in MEN1 syndrome. Our data doubles the number of cases reported in literature on this topic. Furthermore, the present study brings to light important issues that could help to establish the best biochemical and oncological cure for such cases, of which clinicians should be aware to improve the management of MEN1 patients.