Wang HP, Zhu YL, Shao W. Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphoma. World J Gastroenterol 2013; 19(45): 8219-8226 [PMID: 24363512 DOI: 10.3748/wjg.v19.i45.8219]
Corresponding Author of This Article
Wei Shao, MD, Department of Gastroenterology, People’s Hospital of Putuo District, 24F Xincheng District, Zhoushan 316000, Zhejiang Province, China. 667318_won@sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Gastroenterol. Dec 7, 2013; 19(45): 8219-8226 Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8219
Role of Helicobacter pylori virulence factor cytotoxin-associated gene A in gastric mucosa-associated lymphoid tissue lymphoma
Hong-Ping Wang, Yong-Liang Zhu, Wei Shao
Hong-Ping Wang, Yong-Liang Zhu, Gastroenterology Laboratory, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Wei Shao, Department of Gastroenterology, People’s Hospital of Putuo District, Zhoushan 316000, Zhejiang Province, China
Author contributions: Wang HP and Shao W searched the literature and wrote the manuscript; Zhu YL conceived the topic and was involved in writing the manuscript; all authors revised the manuscript.
Supported by Foundation of Scientific Technology Bureau of Zhejiang Province, No. 2010C33118
Correspondence to: Wei Shao, MD, Department of Gastroenterology, People’s Hospital of Putuo District, 24F Xincheng District, Zhoushan 316000, Zhejiang Province, China. 667318_won@sina.com
Telephone: +86-580-3019686 Fax: +86-580-3019686
Received: September 27, 2013 Revised: November 4, 2013 Accepted: November 12, 2013 Published online: December 7, 2013
Core Tip
Core tip: Cytotoxin-associated gene A (CagA) protein encoded by cag pathogenicity island of Helicobacter pylori is a bacterium-derived oncoprotein and is strongly associated with the gastric mucosa-associated lymphoid tissue (MALT) lymphoma. After being translocated into B cells via type IV secretion system in ATP-dependent manner, CagA deregulates several pathways in both tyrosine phosphorylation-dependent and -independent manners, and thereby promotes lymphomagenesis. Two important proteins, p53 and protein tyrosine phosphatases-2, are involved in the malignant transformation induced by CagA. In addition, mucosal inflammation is the foundational mechanism underlying the occurrence and development of gastric MALT lymphoma. However, the exact mechanism by which CagA promotes oncogenesis needs further clarification.
