Topic Highlight
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World J Gastroenterol. Dec 7, 2013; 19(45): 8168-8180
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8168
How antibiotic resistances could change Helicobacter pylori treatment: A matter of geography?
Enzo Ierardi, Floriana Giorgio, Giuseppe Losurdo, Alfredo Di Leo, Mariabeatrice Principi
Enzo Ierardi, Floriana Giorgio, Giuseppe Losurdo, Alfredo Di Leo, Mariabeatrice Principi, Division of Gastroenterology, Department of Emergency and Organ Transplantation, 70124 Bari, Italy
Author contributions: Ierardi E, Di Leo A and Principi M designed the study, revised the manuscript, and approved the final version; Losurdo G and Giorgio F collected the data and revised the final version before approval.
Correspondence to: Enzo Ierardi, Professor, Division of Gastroenterology, Department of Emergency and Organ Transplantation, Viale Pinto, 70124 Bari, Italy. enzo.ierardi@fastwebnet.it
Telephone: +39-80-5592577 Fax: +39-80-5593088
Received: September 23, 2013
Revised: October 18, 2013
Accepted: November 3, 2013
Published online: December 7, 2013
Processing time: 85 Days and 15.8 Hours
Core Tip

Core tip: The present topic outlines the main data regarding antibiotic resistances, paying particular attention to the discrepant results obtained in different geographic areas worldwide, and even in the same districts. Discordances between in vitro and in vivo studies are detailed and the possible factors explaining this phenomenon are analyzed. Finally, the challenge for the future of devising a successful solution to overcome antibiotic resistances is highlighted, and geography is suggested as a relevant matter.