Meta-Analysis
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World J Gastroenterol. Nov 28, 2013; 19(44): 8114-8132
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8114
Laparoscopic vs open total gastrectomy for gastric cancer: A meta-analysis
Jun-Jie Xiong, Quentin M Nunes, Wei Huang, Chun-Lu Tan, Neng-Wen Ke, Si-Ming Xie, Xun Ran, Hao Zhang, Yong-Hua Chen, Xu-Bao Liu
Jun-Jie Xiong, Chun-Lu Tan, Neng-Wen Ke, Si-Ming Xie, Xun Ran, Hao Zhang, Yong-Hua Chen, Xu-Bao Liu, Department of Hepato-Biliary-Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Quentin M Nunes, Wei Huang, NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, University of Liverpool, Liverpool L69 3GA, United Kingdom
Author contributions: Xiong JJ and Nunes QM contributed equally to this work; Liu XB, Chen YH and Zhang H designed the research, and corrected and approved the manuscript; Xiong JJ, Nunes QM and Tan CL developed the literature search and carried out the statistical analyses of the studies; Huang W, Ke NW, Xie SM and Ran X performed data extraction; Xiong JJ, Nunes QM and Huang W wrote the manuscript; All authors read and approved the final manuscript.
Supported by UK/China Postgraduate Scholarships for Excellence, an NIHR Translational Research Fellowship and a Royal College of Surgeons of England-Ethicon Research Fellowship grant
Correspondence to: Xu-Bao Liu, MD, PhD, Professor, Department of Hepato-Biliary-Pancreatic Surgery, West China Hospital, Sichuan University, Guo Xue Rd 37, Chengdu 610041, Sichuan Province, China. liuxb2011@126.com
Telephone: +86-28-85422474 Fax: +86-28-85422872
Received: June 19, 2013
Revised: September 10, 2013
Accepted: September 16, 2013
Published online: November 28, 2013
Processing time: 175 Days and 4.2 Hours
Core Tip

Core tip: Currently, surgical resection is the mainstay treatment for gastric cancer. With technical advances and improved instrumentation, laparoscopic total gastrectomy (LTG) is being used increasingly to treat this malignant disease. However, compared with conventional open total gastrectomy (OTG), the safety and technical feasibility of LTG have not been adequately evaluated. This study clarified that, compared with OTG, LTG has similar short-term oncological outcomes, analgesic use and mortality. Furthermore, LTG was associated with lower intraoperative blood loss and overall complication rate, fewer wound-related complications, quicker recovery of gastrointestinal motility and a shorter hospital stay, albeit with a longer operation time.