Brief Article
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World J Gastroenterol. Nov 28, 2013; 19(44): 8108-8113
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8108
siRNA-targeted inhibition of growth hormone receptor in human colon cancer SW480 cells
Dong Zhou, Jie Yang, Wei-Dong Huang, Jun Wang, Qiang Zhang
Dong Zhou, Jie Yang, Wei-Dong Huang, Jun Wang, Qiang Zhang, Department of General Surgery, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang 441000, Hubei Province, China
Author contributions: Zhou D performed the majority of the experiments; Yang J provided vital reagents and analytical tools and was also involved in editing the manuscript; Huang WD and Wang J coordinated and collected the human material, in addition to providing financial support for this work; Zhang Q designed the study and wrote the manuscript.
Correspondence to: Dong Zhou, MD, Department of General Surgery, Xiangyang Hospital Affiliated to Hubei University of Medicine, Xiangyang 441000, Hubei Province, China. tbw120@163.com
Telephone: +86-710-3420052 Fax: +86-710-3420176
Received: May 24, 2013
Revised: October 12, 2013
Accepted: October 19, 2013
Published online: November 28, 2013
Processing time: 200 Days and 19.4 Hours
Core Tip

Core tip: Human growth hormone receptor (GHR) is highly expressed in colon cancer tissues. GH/GHR plays an important role in colon cancer emergence and development. After specific binding of GH to GHR in tumor tissues, the JAK-STAT signaling pathway is activated, resulting in improved cell growth and proliferation. small interfering RNAs (siRNAs)-targeted inhibition of the human GHR gene was used to investigate its impact on the emergence and development of colon cancer and to determine how human colon cancer cells respond to GHR suppression. The siRNA-containing plasmid could suppress GHR expression in colon cancer cells and exhibited anti-tumor effects in nude mice.