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World J Gastroenterol. Nov 28, 2013; 19(44): 8056-8064
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8056
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.8056
Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy
Rossana C Soletti, Kelly Z Alves, João C Machado, Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-972, Brazil
Marcelo AP de Britto, João C Machado, Post-Graduation Program in Surgical Sciences, Department of Surgery, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-972, Brazil
Dyanna G de Matos, Helena L Borges, Biomedical Science Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-972, Brazil
Mônica Soldan, Division of Gastroenterology, Endoscopy Unit, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, RJ 21941-972, Brazil
Author contributions: Soletti RC, de Britto MAP and Machado JC designed the research; Soletti RC, de Britto MAP, Soldan M and Machado JC performed the experiments; Soletti RC and Alves KZ analyzed the data; Borges HL contributed with reagents, mice and critical analysis of the manuscript; de Matos DG genotyped the mice; Soletti RC and Machado JC wrote the paper; and all authors provided final approval of the article.
Supported by National Council for Scientific and Technological Development (CNPq); Brazilian Federal Agency for Support and Evaluation of Higher Education (CAPES) and Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro (FAPERJ)
Correspondence to: João Carlos Machado, Professor, Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, PO Box 68510, Rio de Janeiro, RJ 21941-972, Brazil. jcm@peb.ufrj.br
Telephone: +55-21-25628578 Fax: +55-21-25628591
Received: February 22, 2013
Revised: July 17, 2013
Accepted: July 23, 2013
Published online: November 28, 2013
Processing time: 291 Days and 17.8 Hours
Revised: July 17, 2013
Accepted: July 23, 2013
Published online: November 28, 2013
Processing time: 291 Days and 17.8 Hours
Core Tip
Core tip: This paper employed imaging methods, endoluminal ultrasonic biomicroscopy (eUBM) associated to colonoscopy, in a longitudinal study to evaluate the progression of chemically-induced colonic lesions in mice, during a period of two months. The eUBM method complemented colonoscopy and enhanced the study, once the ultrasonic images allowed the detection of lesions underneath the epithelium. Potential future application of eUBM combined with colonoscopy could be in the monitoring of therapeutic efficacy of chemotherapeutic drugs in vivo.