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World J Gastroenterol. Nov 28, 2013; 19(44): 7910-7921
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.7910
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.7910
Scotomas in molecular virology and epidemiology of hepatitis C virus
Yue Wang, National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China
Yue Wang, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, Zhejiang Province, China
Author contributions: Wang Y solely contributed to this manuscript.
Correspondence to: Yue Wang, Professor, National Institute for Viral Disease Control and Prevention, China CDC, Xicheng District, Yingxin Rd, Beijing 100052, China. euy-tokyo@umin.ac.jp
Telephone: +86-10-63555751 Fax: +86-10-63510565
Received: September 25, 2013
Revised: October 22, 2013
Accepted: November 3, 2013
Published online: November 28, 2013
Processing time: 76 Days and 21.5 Hours
Revised: October 22, 2013
Accepted: November 3, 2013
Published online: November 28, 2013
Processing time: 76 Days and 21.5 Hours
Core Tip
Core tip: The review summarizes the advancements, as well as remaining scotomas, in the molecular virology of hepatitis C virus (HCV). We emphasize the contributions of HuH-7 hepatocellular carcinoma cell line to development of the HCV replicon, cell culture-derived HCV, and HCV pseudoparticles. In addition, we reiterate the importance of epidemiological issues because accurate assessment of HCV-related disease burden has been overlooked. This review provides a history of the fight against HCV, which has required scientists to avail themselves to the best of modern biomedical technology, which in turn has enriched our knowledge of virology and cellular physiology.