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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Nov 28, 2013; 19(44): 7836-7845
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.7836
Published online Nov 28, 2013. doi: 10.3748/wjg.v19.i44.7836
Non-coding RNAs in hepatitis C-induced hepatocellular carcinoma: Dysregulation and implications for early detection, diagnosis and therapy
Weihong Hou, Herbert L Bonkovsky, the Liver, Digestive and Metabolic Disorders Laboratory, and the Liver-Biliary-Pancreatic Center, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, United States
Author contributions: Hou W conceived the topic, reviewed the literature and wrote the manuscript; Bonkovsky HL reviewed the literature and revised this paper critically.
Supported by A grant from the NIH/NHLBI, No. HL117199; Institutional funds from the Carolinas Health Care Foundation and Carolinas Medical Center
Correspondence to: Weihong Hou, PhD, Research Scientist, the Liver, Digestive and Metabolic Disorders Laboratory, and the Liver-Biliary-Pancreatic Center, Cannon Research Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, United States. weihong.hou@carolinashealthcare.org
Telephone: +1-704-3559683 Fax: +1-704-3557648
Received: September 28, 2013
Revised: October 14, 2013
Accepted: November 12, 2013
Published online: November 28, 2013
Processing time: 74 Days and 9.4 Hours
Revised: October 14, 2013
Accepted: November 12, 2013
Published online: November 28, 2013
Processing time: 74 Days and 9.4 Hours
Core Tip
Core tip: Regulatory non-coding RNAs (ncRNAs), mainly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are likely to play important roles in a variety of biological processes, including development and progression of hepatitis C-induced hepatocellular carcinoma (HCC). In this review, we focus on recent studies of ncRNAs, especially miRNAs and lncRNAs associated with hepatitis C virus (HCV)-induced HCC. We summarize those ncRNAs aberrantly expressed in HCV-induced HCC and highlight the potential of these ncRNAs to aid in early detection, diagnosis and therapy of HCV-induced HCC. Further, we discuss the limitations of current studies, and suggest future directions for research in the field.