Zhang ZQ, Li XJ, Liu GT, Xia Y, Zhang XY, Wen H. Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray. World J Gastroenterol 2013; 19(43): 7795-7803 [PMID: 24282368 DOI: 10.3748/wjg.v19.i43.7795]
Corresponding Author of This Article
Hao Wen, Professor, Department of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, the First Affiliated Hospital, Xinjiang Medical University, No. 137 Liyushan South Road, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China. zhangzhiqiang011@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Qiang Zhang, Yu Xia, Department of Gastroenterology, the First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Xiu-Juan Li, Xiang-Yang Zhang, Department of Pathophysiology, Collage of Preclinical Medicine, Xinjiang Medical University, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Gui-Tao Liu, Occupational Diseases Prevention and Treatment Institution, the Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Hao Wen, Department of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, the First Affiliated hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Author contributions: Zhang ZQ and Li XJ contributed equally to this work, designed this study, performed the major experiments, analyzed the data and wrote the manuscript; Liu GT, Zhang XY and Xia Y participated in the performance of experiments and statistical analyses; and Wen H designed the study together and critically reviewed the manuscript.
Supported by National Natural Science Foundation of China, No. 81001101; Natural Science Foundation of Xinjiang Uygur Autonomous Region, China, No.2010211B20
Correspondence to: Hao Wen, Professor, Department of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, the First Affiliated Hospital, Xinjiang Medical University, No. 137 Liyushan South Road, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China. zhangzhiqiang011@126.com
Telephone: +86-991-4324139 Fax: +86-991-4324139
Received: June 30, 2013 Revised: August 23, 2013 Accepted: September 15, 2013 Published online: November 21, 2013 Processing time: 170 Days and 14.2 Hours
Core Tip
Core tip: The anti-inflammatory protein Annexin A1 (ANXA1) mediates various important physiological and pathophysiological processes. Evidence has shown that ANXA1 is related to the development and progression of human multi-tumours. However, the ANXA1 expression in gastric adenocarcinoma of Chinese patients and the relationship between this protein and its clinicopathological parameters remain unclear. In the present study, the ANXA1 expression in gastric adenocarcinoma of Chinese patients was investigated by proteomics and western blot analysis. Authors examined 75 pairs of gastric adenocarcinoma and paracarcinoma tissues by tissue microarray to determine the presence of ANXA1 by immunohistochemistry. They found that ANXA1 expression was upregulated and involved in human gastric adenocarcinoma invasion and metastasis. Our findings suggested that ANXA1 might be used as a valuable biomarker in clinical diagnosis, prognostic prediction and targeted therapy of gastric cancer.
