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World J Gastroenterol. Nov 21, 2013; 19(43): 7701-7710
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7701
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7701
Is early limited surgery associated with a more benign disease course in Crohn’s disease?
Petra Anna Golovics, Barbara Dorottya Lovasz, Michael Mandel, Zsuzsanna Vegh, Peter Laszlo Lakatos, Lajos Sandor Kiss, First Department of Medicine, Semmelweis University, H-1083 Budapest, Hungary
Laszlo Lakatos, Tunde Pandur, Istvan Szita, Department of Medicine, Csolnoky F Province Hospital, H-8200 Veszprem, Hungary
Attila Nagy, Department of Surgery, Csolnoky F Province Hospital, H-8200 Veszprem, Hungary
Mihaly Balogh, Department of Medicine, Grof Eszterhazy Hospital, H-8500 Papa, Hungary
Csaba Molnar, Department of Infectious Diseases, Magyar Imre Hospital, H-8400 Ajka, Hungary
Erzsebet Komaromi, Department of Gastroenterology, Municipal Hospital, H-8100 Varpalota, Hungary
Gabor Veres, First Department of Pediatrics, Semmelweis University, H-1083 Budapest, Hungary
Author contributions: Golovics PA, Lakatos L, Lovasz BD and Vegh Z contributed to data collection and validation, database construction, and manuscript preparation and revision; Nagy A, Pandur T, Szita I, Balogh M, Molnar C and Komaromi E contributed to data collection and critical revision of the manuscript; Mandel M, Veres G and Kiss LS contributed to data validation and critical revision of the manuscript; Lakatos PL contributed tostudy design, data collection and validation, database construction, statistical analysis, and manuscript preparation; all authors have approved the final draft submitted.
Supported by Unrestricted research grant by Schering-Plough Hungary/MSD to Lakatos PL and Lakatos L
Correspondence to: Peter Laszlo Lakatos, MD, PhD, First Department of Medicine, Semmelweis University, Koranyi S. 2/A, H-1083 Budapest, Hungary. lakatos.peter_laszlo@med.semmelweis-univ.hu
Telephone: +36-1-4591500 Fax: +36-1-3130250
Received: July 1, 2013
Revised: August 2, 2013
Accepted: September 13, 2013
Published online: November 21, 2013
Revised: August 2, 2013
Accepted: September 13, 2013
Published online: November 21, 2013
Core Tip
Core tip: An alternative approach may be early limited resective surgery in a well-selected group of patients with Crohn’s disease. In this population-based study, we found that overall exposure to steroids and biological agents was lower in patients with early limited resective surgery; observed surgery rates were also lower, yet reoperation rates did not differ in the two groups after matching on propensity scores.