Review
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World J Gastroenterol. Nov 21, 2013; 19(43): 7594-7602
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7594
Role of sirtuins in ischemia-reperfusion injury
Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Hassen Ben Abdennebi, Joan Roselló-Catafau
Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Experimental Hepatic Ischemia-Reperfusion Unit, Institut of Biomedical Research of Barcelona-Spanish National Research Council, Barcelona, 08036 Catalonia, Spain
Hassen Ben Abdennebi, Molecular Biology and Anthropology applied to development and health (UR12ES11), Faculty of Pharmacy, Monastir 5000, Tunisia
Joan Roselló-Catafau, Experimental Pathology Department, Institute of Biomedical Research of Barcelona-Spanish National Research Council, Barcelona, 08036 Catalonia, Spain
Author contributions: Pantazi E, Zaouali MA, Folch-Puy E and Bejaoui M wrote the article and reviewed the literature; Ben Abdennebi H and Roselló-Catafau J made significant contributions to the design and revision of the manuscript; all authors have read and approved the final manuscript.
Supported by AGAUR, No. 2012FI_B00382, Generalitat de Catalunya, Barcelona, Spain, to Pantazi E; CSIC for the development program to Bejaoui M, No. I-COOP0005; The Fondo de Investigaciones Sanitarias, No. FIS PI12/00519
Correspondence to: Joan Rosello-Catafau, PhD, Experimental Pathology Department, Institute of Biomedical Research of Barcelona-Spanish National Research Council, C/ Rosselló 161, 7th floor, Barcelona, 08036 Catalonia, Spain. jrcbam@iibb.csic.es
Telephone: +34-93-3638300 Fax: +34-93-3638301
Received: June 28, 2013
Revised: September 16, 2013
Accepted: September 29, 2013
Published online: November 21, 2013
Processing time: 172 Days and 10.5 Hours
Core Tip

Core tip: Sirtuins are responsible for the regulation of protein activation by deacetylating a range of proteins that play important roles in the pathophysiology of various diseases. The present review summarizes the beneficial effects of sirtuins 1 and 3, the two most prominent sirtuins involved in mammalian energy homeostasis and oxidative stress. We conclude that both sirtuins might be attractive targets for counteracting the detrimental effects of ischemia-reperfusion injury.