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World J Gastroenterol. Nov 14, 2013; 19(42): 7369-7373
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7369
Intestinal acyl-CoA synthetase 5: Activation of long chain fatty acids and behind
Christina Klaus, Min Kyung Jeon, Elke Kaemmerer, Nikolaus Gassler
Christina Klaus, Min Kyung Jeon, Elke Kaemmerer, Nikolaus Gassler, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
Author contributions: Klaus C and Gassler N designed and wrote the article; Jeon MK and Kaemmerer E critically reviewed the literature and made technical notes.
Correspondence to: Nikolaus Gassler, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. ngassler@ukaachen.de
Telephone: +49-241-8088897 Fax: +49-241-8082439
Received: June 21, 2013
Revised: July 20, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Processing time: 149 Days and 16.5 Hours
Core Tip

Core tip: Acyl-CoA synthetase 5 (ACSL5) activates long-chain fatty acids by coenzyme A linkage and plays a key role in fatty acid metabolism. On the basis of its mitochondrial localization, ACSL5 forms an exceptional member among the acyl-CoA synthetase family. Although its various functions are not yet fully understood, ACSL5 seems to represent a modifier of cellular vitality along the crypt-villus-axis.