Brief Article
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World J Gastroenterol. Nov 7, 2013; 19(41): 7177-7182
Published online Nov 7, 2013. doi: 10.3748/wjg.v19.i41.7177
Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP
Yun Bian, Li Wang, Chao Chen, Jian-Ping Lu, Jia-Bao Fan, Shi-Yue Chen, Bing-Hui Zhao
Yun Bian, Li Wang, Chao Chen, Jian-Ping Lu, Jia-Bao Fan, Shi-Yue Chen, Bing-Hui Zhao, Department of Radiology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Jia-Bao Fan, Department of laboratory, the 411st Hospital of Chinese PLA, Shanghai 200081, China
Author contributions: Bian Y performed the majority of experiments; Wang L, Chen C and Lu JP provided vital reagents and analytical tools and were also involved in editing the manuscript; Fan JB, Chen SY, Zhao BH provided the technical support; Bian Y wrote the manuscript.
Correspondence to: Li Wang, MD, Department of Radiology, Changhai Hospital, the Second Military Medical University, 168 Changhai Road, Shanghai 200433, China. wangli_changhai@163.com
Telephone: +86-13-816357024 Fax: +86-21-65254525
Received: July 27, 2013
Revised: September 4, 2013
Accepted: September 15, 2013
Published online: November 7, 2013
Processing time: 112 Days and 18 Hours
Core Tip

Core tip: After all subjects were injected secretin, the results of secretin enhanced magnetic resonance cholangiopancreatography (SMRCP) were that the mean values of PFR and PT were 8.18 ± 1.11 mL/min, 5.76 ± 1.71 min for normal; 7.27 ± 2.04 mL/min, 7.71 ± 2.55 min for mild chronic pancreatitis (CP); 4.98 ± 2.57 mL/min, 9.10 ± 3.00 min for moderate CP; 4.13 ± 1.83 mL/min, 12.33 ± 1.55 min for advanced CP. Statistically significant difference in PFR and PT was observed between health and CP. Also, there was correlation and consistency between Quantification of secretin enhanced magnetic resonance cholangiopancreatography and enzyme-linked immunosorbent assay test. SMRCP can provide a safe, non-invasive and efficient method to evaluate the exocrine function of the pancreas.