Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype

doi:10.3748/wjg.v19.i41.7078

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 7, 2013; 19(41): 7078-7088
Published online Nov 7, 2013. doi: 10.3748/wjg.v19.i41.7078

Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype

Jae Yun Lim, Sun Och Yoon, So-Young Seol, Soon Won Hong, Jong Won Kim, Seung Ho Choi, Ju-Seog Lee, Jae Yong Cho

Jae Yun Lim, So-Young Seol, Jae Yong Cho, Department of Medical Oncology, Gangnam Severance Cancer Hospital, Yonsei University College of Medicine, Seoul 135-720, South Korea

Sun Och Yoon, Soon Won Hong, Department of Pathology, Gangnam Severance Cancer Hospital, Yonsei University College of Medicine 135-720, Seoul, South Korea

Jong Won Kim, Seung Ho Choi, Department of Surgery, Gangnam Severance Cancer Hospital, Yonsei University College of Medicine, Seoul 135-720, South Korea

Jae Yun Lim, Ju-Seog Lee, Department of Systems Biology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States

Author contributions: Cho JY and Lee JS designed the study; Lim JY, Yoon SO, Seol SY, Hong SW, Kim JW and Choi SH contributed to performing experiment and acquisition of data; Lim JY and Cho JY analyzed and interpreted the data; Lim JY and Cho JY wrote the paper.

Supported by The Faculty Research Grant of Yonsei University College of Medicine (6-2011-0113); the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology, No. 2010-0024248

Correspondence to: Jae Yong Cho, MD, PhD, Professor, Department of Medical Oncology, Gangnam Severance Cancer Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam-gu, Seoul 135-720, South Korea. chojy@yuhs.ac

Telephone: +82-2-20194363 Fax: +82-2-34633882

Received: March 26, 2013
Revised: July 2, 2013
Accepted: July 9, 2013
Published online: November 7, 2013

Core Tip

Core tip: Using an integrative analysis of the tumor transcriptome and protein expression profiles obtained by microarray techniques, we have elucidated the molecular biologic characteristics of a poor prognosis gastric cancer subgroup. Overexpression of miR196b and Homeobox A10 are implicated in gastric cancer, particularly in tumors with poor prognosis features. We anticipate this integrative approach will contribute to the characterization of cancer heterogeneity and the development of personalized therapy through the identification of cancer targets.