Choi DH, Lee SJ, Kang CD, Park MO, Choi DW, Kim TS, Lee W, Cho BR, Kim YH, Lee BK, Ryu DR, Lee JW. Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans. World J Gastroenterol 2013; 19(38): 6453-6457 [PMID: 24151364 DOI: 10.3748/wjg.v19.i38.6453]
Corresponding Author of This Article
Dong Ryeol Ryu, MD, Associate Professor of Internal Medicine, Department of Internal Medicine, Kangwon National University School of Medicine, Hyoja-dong, Chuncheon 200-701, South Korea. rdr0203@hanmail.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Oct 14, 2013; 19(38): 6453-6457 Published online Oct 14, 2013. doi: 10.3748/wjg.v19.i38.6453
Nonalcoholic fatty liver disease is associated with coronary artery disease in Koreans
Dae Hee Choi, Sung Joon Lee, Chang Don Kang, Myoung Ok Park, Dong Wook Choi, Tae Suk Kim, Wonho Lee, Byung Ryul Cho, Yong Hoon Kim, Bong-ki Lee, Dong Ryeol Ryu, Ji Won Lee
Dae Hee Choi, Sung Joon Lee, Chang Don Kang, Myoung Ok Park, Dong Wook Choi, Tae Suk Kim, Wonho Lee, Byung Ryul Cho, Yong Hoon Kim, Bong-ki Lee, Dong Ryeol Ryu, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 200-701, South Korea
Ji Won Lee, Department of Radiology, Kangwon National University School of Medicine, Chuncheon 200-701, South Korea
Author contributions: Choi DH contributed to conception and design, reviewed the literature and drafted the paper; Lee SJ, Kang CD, Park MO, Choi DW, Kim TS, Lee W, Cho BR, Kim YH, Lee B and Lee JW collected data; Ryu DR reviewed data and edited the paper.
Supported by A 2009 Research Grant from Kangwon National University
Correspondence to: Dong Ryeol Ryu, MD, Associate Professor of Internal Medicine, Department of Internal Medicine, Kangwon National University School of Medicine, Hyoja-dong, Chuncheon 200-701, South Korea. rdr0203@hanmail.net
Telephone: +82-33-2582454 Fax: +82-33-2582404
Received: June 20, 2013 Revised: August 12, 2013 Accepted: August 20, 2013 Published online: October 14, 2013 Processing time: 117 Days and 0.9 Hours
Core Tip
Core tip: This article shows that angiographically proven coronary artery stenosis is strongly associated with nonalcoholic fatty liver disease (NAFLD) in a grade-dependent manner. Although many recent studies used coronary artery calcification score, carotid artery intima-media thickness, or carotid artery plaque measurements as surrogate markers for coronary artery disease (CAD), we evaluated the interaction between fatty liver and cardiovascular outcomes using coronary angiograms in a prospective case-controlled study. Because the pathogenesis of NAFLD and CAD is not fully elucidated, we attempted to identify mediators of these diseases and believe that adiponectin might be related to the development and progression of CAD in patients with NAFLD.
