Case Report
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World J Gastroenterol. Oct 7, 2013; 19(37): 6299-6303
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6299
A case of plasmablastic lymphoma of the liver without human immunodeficiency virus infection
Joji Tani, Hisaaki Miyoshi, Takako Nomura, Hirohito Yoneyama, Hideki Kobara, Hirohito Mori, Asahiro Morishita, Takashi Himoto, Tsutomu Masaki
Joji Tani, Hisaaki Miyoshi, Takako Nomura, Hirohito Yoneyama, Hideki Kobara, Hirohito Mori, Asahiro Morishita, Takashi Himoto, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, Kagawa 761-0793, Japan
Takashi Himoto, Department of Integrated Medicine, Kagawa University Faculty of Medicine, Kagawa 761-0793, Japan
Author contributions: Tani J, Masaki T designed the report; Tani J, Miyoshi H, Nomura T, Yoneyama H, Kobara H, Mori H, Morishita A and Himoto T were attending doctors for the patients; Masaki T organized the report; and Tani J wrote paper.
Correspondence to: Joji Tani, MD, Department of Gastroenterology and Neurology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. georget@med.kagawa-u.ac.jp
Telephone: +81-87-8912156 Fax: +81-87-8912158
Received: July 18, 2013
Revised: August 7, 2013
Accepted: August 17, 2013
Published online: October 7, 2013
Processing time: 137 Days and 0.8 Hours
Core Tip

Core tip: Plasmablastic lymphoma (PBL) is a rare B-cell lymphoma. Although PBL is observed in the oral cavity of human immunodeficiency virus (HIV)-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. We present a case of PBL of the liver in a 79-year-old HIV-negative male. Histopathological examination showed large-cell lymphoma with plasmacytic differentiation diffusely infiltrating the liver and involving the surrounding organs. The neoplastic cells were diffusely positive for CD30, Epstein-Barr virus, Bob-1, and CD38. The present case appears to be the first report of PBL with initial presentation in the liver in a patient without HIV infection.