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World J Gastroenterol. Oct 7, 2013; 19(37): 6265-6271
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6265
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6265
Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells
Xiao-Jun Liu, Zhao-Feng Chen, Hai-Long Li, Ze-Nan Hu, Ai-Ping Tian, Da Zhao, Yong-Ning Zhou, Liang Qiao, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Xiao-Jun Liu, Zhao-Feng Chen, Min Liu, Yong-Ning Zhou, Liang Qiao, Key Laboratory for Gastrointestinal Disease of Gansu Province, Lanzhou 730000, Gansu Province, China
Jing Wu, Beijing Shijitan Hospital, Beijing 100038, China
Liang Qiao, Storr Liver Unit, Westmead Millennium Institute, Western Clinical School of the Faculty of Medicine at Westmead Hospital, Westmead NSW 2145, Australia
Author contributions: Zhou YN and Qiao L designed the research; Liu XJ, Chen ZF, Li HL, Tian AP, Hu ZN and Liu M performed the laboratory studies; Wu J and Zhao D analyzed the data; Liu XJ and Chen ZF wrote the paper.
Supported by The National Natural Science Funding of China, No. 81172366; and the Fundamental Research Funds for the Central Universities, No. lzujbky-2012-224; and the Gansu Special Program for High Technology Research and Development, No. 0912TCYA027
Correspondence to: Dr. Liang Qiao, MD, PhD, Storr Liver Unit, Westmead Millennium Institute, Western Clinical School of the Faculty of Medicine at Westmead Hospital, Westmead NSW 2145, Australia. liang.qiao@sydney.edu.au
Telephone: +61-2-98459132 Fax: +61-2-98459103
Received: June 2, 2013
Revised: July 15, 2013
Accepted: August 20, 2013
Published online: October 7, 2013
Processing time: 137 Days and 20.5 Hours
Revised: July 15, 2013
Accepted: August 20, 2013
Published online: October 7, 2013
Processing time: 137 Days and 20.5 Hours
Core Tip
Core tip: Cyclooxygenase-2 (COX-2) plays an important role in transcriptional regulation of E-cadherin in gastric cancer and other malignancies. On the contrary, prostaglandin E2 (PGE2) promotes invasion of tumor cells through down-regulating the expression of E-cadherin. Our study has provided further evidence that COX-2 functions upstream of nuclear factor-κB in the regulation of Snail and E-cadherin in gastric cancer cells. Blockade of COX-2 activity or inhibition of PGE2 production may offer some benefit in the chemoprevention and treatment of gastric cancer.