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World J Gastroenterol. Oct 7, 2013; 19(37): 6258-6264
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6258
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6258
Research on stress-induced apoptosis of natural killer cells and the alteration of their killing activity in mouse liver
Zhen Ma, Xin Zhou, Hai-Long Yu, Ming-Qi Li, Xue-Feng Bai, Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang Province, China
Yang Liu, Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Chikako Tomiyama-Miyaji, Toru Abo, Department of Immunology, Niigata University School of Medicine, Niigata 951-8510, Japan
Author contributions: Ma Z and Liu Y carried out the experimental work; Ma Z and Liu Y contributed equally to this study and should be regarded as first joint authors; Ma Z, Liu Y, Zhou X and Li MQ participated in the data collection; Zhou X contributed to the analysis of data and preparation of the manuscript; Yu HL carried out partial experimental work and manuscript preparation; Li MQ carried out the data interpretation; Tomiyama-Miyaji C, Abo T and Bai XF participated in the study design; Bai XF carried out the coordination of experimental work, the analysis and interpretation of data and drafted the manuscript.
Supported by The National Natural Science Foundation of China, No.30671899, No.30540012
Correspondence to: Xue-Feng Bai, PhD, Professor, Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Haping Street 150, Harbin 150040, Heilongjiang Province, China. drbaixuefeng@163.com
Telephone: +86-451-86298096 Fax: +86-451-86298756
Received: May 7, 2013
Revised: July 21, 2013
Accepted: August 8, 2013
Published online: October 7, 2013
Processing time: 144 Days and 16.7 Hours
Revised: July 21, 2013
Accepted: August 8, 2013
Published online: October 7, 2013
Processing time: 144 Days and 16.7 Hours
Core Tip
Core tip: Hepatic natural killer (NK) cells are classified into macrophage-1 (Mac-1)+ and Mac-1- cells, and the different functional characteristics of Mac-1+ or Mac-1- NK cells in response to stress stimulation are confirmed. This study further proves the heterogeneity of NK cell function, and the results provide a reference for preventing the immune system damage caused by stress.