Elkady A, Aboulfotuh S, Ali EM, Sayed D, Abdel-Aziz NM, Ali AM, Murakami S, Iijima S, Tanaka Y. Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt. World J Gastroenterol 2013; 19(37): 6214-6220 [PMID: 24115819 DOI: 10.3748/wjg.v19.i37.6214]
Corresponding Author of This Article
Yasuhito Tanaka, MD, PhD, Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. ytanaka@med.nagoya-cu.ac.jp
Research Domain of This Article
Virology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Abeer Elkady, Shuko Murakami, Sayuki Iijima, Yasuhito Tanaka, Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan
Abeer Elkady, Department of Clinical and Chemical Pathology, Medical School of South Valley University, Qena 83523, Egypt
Sahar Aboulfotuh, Department of Clinical and Chemical Pathology, Medical School of Sohag University, Sohag 82524, Egypt
Elsayed Mostafa Ali, Department of Medical Oncology, Medical School of Sohag University, Sohag 82524, Egypt
Douaa Sayed, Department of Clinical and Chemical Pathology, South Egypt Cancer Institute, Assuti 71515, Egypt
Nashwa M Abdel-Aziz, Amany M Ali, Department of Medical Oncology, South Egypt Cancer Institue, 71515 Assuit, Egypt
Author contributions: Elkady A and Tanaka Y designed the study, directed its implementation, supervised all of the field activities, and contributed to the analysis and interpretation of the data as well as to the redaction of the manuscript; Ali EM, Aboulfotuh S, Sayed D, Abdel-Aziz NM, and Ali AM contributed to the collection of the materials and patient data; Murakami S and Iijima S contributed to the analysis and interpretation of the data.
Supported by The Grant for National Center For Global Health and Medicine (22A-9); a Grant-in-Aid form Japan Society for the Promotion of Science (JSPS) Fellows (21.09355) and a Grant-in-Aid form the Ministry of Health, Labour and Welfare of Japan
Correspondence to: Yasuhito Tanaka, MD, PhD, Department of Virology and Liver Unit, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. ytanaka@med.nagoya-cu.ac.jp
Telephone: +81-52-8538191 Fax: +81-52-8420021
Received: April 27, 2013 Revised: July 24, 2013 Accepted: August 4, 2013 Published online: October 7, 2013 Processing time: 174 Days and 2.2 Hours
Core Tip
Core tip: The study aimed to investigate characteristics of hepatitis B virus (HBV) implicated in HBV reactivation in patients with hematological malignancies receiving immunosuppressive therapy in Egypt. Fifty-three hepatitis B surface antigen (HBsAg)-negative patients treated with chemotherapy were included in the study. The incidence of HBV reactivation was 9.4% among the studied cohort, and all of the affected individuals were positive for HBsAg as well as antibodies to the hepatitis B core antigen. The present study provides further evidence via molecular evolutionary analysis of the development of HBV reactivation from an occult HBV infection. Past infection with HBV is a risk factor for HBV reactivation in Egypt. Mandatory antibodies to the core antigen screening prior to chemotherapy in patients with hematological malignancies is suggested.
