Brief Article
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World J Gastroenterol. Sep 21, 2013; 19(35): 5904-5909
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5904
Influence of chronic HBV infection on superimposed acute hepatitis E
Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li, Qi-Huan Xu
Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li, Qi-Huan Xu, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Cheng SH and Mai L contributed equally to this work; Cheng SH, Mai L and Xu QH designed the research; Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM and Li G performed the research; Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H and Shu X collected the data; Cheng SH and Mai L analyzed the data; Cheng SH, Mai L and Xu QH wrote the manuscript.
Correspondence to: Qi-Huan Xu, Professor, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou 510630, Guangdong Province, China. xqh03030513@aliyun.com
Telephone: +86-20-85253179 Fax: +86-20-85253179
Received: May 5, 2013
Revised: July 24, 2013
Accepted: August 4, 2013
Published online: September 21, 2013
Processing time: 139 Days and 8.9 Hours
Core Tip

Core tip: Previous studies have shown that chronic hepatitis B virus (HBV) infection has a negative impact on superimposed acute hepatitis E. However, it remains unknown whether the disease severity of acute hepatitis E correlates with the underlying HBV replication status or with liver histological lesions. Our study showed that the disease severity of acute hepatitis E correlated not with the HBV replication status (based on the status of hepatitis B e antigen and HBV DNA), but rather with the presence of underlying cirrhosis. This finding raised the question of whether anti-HBV treatment improves the outcome of liver failure caused by HBV-hepatitis E virus superinfection. We found that anti-HBV treatment could not improve the prognosis of such liver failure.