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World J Gastroenterol. Sep 21, 2013; 19(35): 5897-5903
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5897
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5897
Association between UCP3 gene polymorphisms and nonalcoholic fatty liver disease in Chinese children
Yan-Ping Xu, Jun-Fen Fu, Department of Endocrinology, Children’s Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Li Liang, Chun-Lin Wang, Department of Pediatrics, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Pei-Ning Liu, Department of Child Health Care, the Affiliated Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Lan-Qiu Lv, Department of Child Health Care, Ningbo Women and Children’s Hospital, Ningbo 315000, Zhejiang Province, China
Yi-Min Zhu, Department of Epidemiology and Biostatistics, Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Xu YP performed the research, statistical analysis and wrote the manuscript; Liang L contributed to the conception and design of the study; Wang CL and Fu JF contributed to collecting and processing the data; Liu PN, Lv LQ and Zhu YM contributed to the control group blood collecting.
Supported by Zhejiang Provincial Natural Science Foundation of China, No. Y2090137; the National Key Technology R and D Program of China, No. 2012BAI02B03; the Fundamental Research Funds for the Central Universities, Ministry of Education, China, No. 2011KYJD008; and National Natural Science Foundation of China, No. J20121252, No.81200460
Correspondence to: Li Liang, Professor, Department of Pediatrics, the First Affiliated Hospital, College of Medicine, Zhejiang University; 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zdliangli@163.com
Telephone: +86-571-87061007 Fax: +86-571-87033296
Received: April 11, 2013
Revised: June 18, 2013
Accepted: August 16, 2013
Published online: September 21, 2013
Processing time: 162 Days and 15.9 Hours
Revised: June 18, 2013
Accepted: August 16, 2013
Published online: September 21, 2013
Processing time: 162 Days and 15.9 Hours
Core Tip
Core tip: There are few population-based prevalence studies of pediatric nonalcoholic fatty liver disease (NAFLD). Uncoupling protein 3 (UCP3) is considered to be associated with obesity, given the role for UCP3 in the regulation of energy and lipid metabolism. This is the first study to report that there significant difference of body height, waist and hip circumference between CC (mutant type group) and CT+TT group with and without rs1800849 variation were found. This study confirmed the hypothesis that polymorphisms of the UCP3 are associated with the occurrence of NAFLD. These variations could be useful for the diagnosis and/or prognosis of NAFLD.