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World J Gastroenterol. Sep 21, 2013; 19(35): 5883-5888
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5883
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5883
Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia
Song-Seng Loke, Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Kuender D Yang, Department of Medical Research, Show Chwan Memorial Hospital, Taichung 40601, Taiwan
Kuang-Den Chen, Center for Translational Research in Biomedical Science, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
Jung-Fu Chen, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
Author contributions: Loke SS, Chen KD and Chen JF contributed to design the study. Loke SS wrote this manuscript and performed the research; Yang KD contributed to design the study and revised the paper critically; Chen KD analyzed the data; Chen JF performed the research.
Correspondence to: Song-Seng Loke, MD, Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Dapi Road, Niaosong District, Kaohsiung 833, Taiwan. loke@adm.cgmh.org.tw
Telephone: +886-7-7317123 Fax: +886-7-7317123
Received: February 26, 2013
Revised: June 13, 2013
Accepted: July 18, 2013
Published online: September 21, 2013
Processing time: 210 Days and 14.7 Hours
Revised: June 13, 2013
Accepted: July 18, 2013
Published online: September 21, 2013
Processing time: 210 Days and 14.7 Hours
Core Tip
Core tip: A cross-sectional, case control study of subjects who underwent upper endoscopy during a health examination was conducted. Metabolic syndrome components, body mass index, liver function, and dyslipidemia were compared between individuals with and without erosive esophagitis. Risk factors for erosive esophagitis were evaluated. Erosive esophagitis was diagnosed in 507 of 5015 subjects who were individually age- and sex-matched to 507 esophagitis-free control subjects. In addition to metabolic syndrome, we also found that abnormal liver function and predictors of future coronary heart disease were associated with erosive esophagitis.