Brief Article
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World J Gastroenterol. Sep 21, 2013; 19(35): 5870-5876
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5870
ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population
Dong-Hyuk Yim, Yan-Wei Zhang, Sang-Yong Eom, Sun In Moon, Hyo-Yung Yun, Young-Jin Song, Sei-Jin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Jong-Young Lee, Yong-Dae Kim, Heon Kim
Dong-Hyuk Yim, Sang-Yong Eom, Sun In Moon, Yong-Dae Kim, Heon Kim, Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea
Yan-Wei Zhang, Key Laboratory of Molecular Biology of Guangdong Province, Center for Disease Control and Prevention, Shenzhen 518020, Guangdong Province, China
Hyo-Yung Yun, Young-Jin Song, Department of Surgery, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea
Sei-Jin Youn, Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-763, South Korea
Taisun Hyun, Department of Food and Nutrition, Chungbuk National University, Cheongju 361-763, South Korea
Joo-Seung Park, Department of Surgery, College of Medicine, Eulji University, Daejon 301-746, South Korea
Byung Sik Kim, Department of Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul 680-749, South Korea
Jong-Young Lee, Center for Genome Science, National Institute of Health, Chungcheongbuk-do 363-951, South Korea
Author contributions: Lee JY, Kim YD and Kim H designed the study protocol; Eom SY, Yim DH, Moon SI and Zhang YW performed the statistical analysis and data interpretation; Song YJ, Yun HY, Park JS, Youn SJ, Kim BS and Hyun T contributed equally to this study through the selection of subjects, sampling, and clinical data acquisition; Yim DH, Kim YD and Kim H drafted the manuscript.
Supported by The National R and D Program for Cancer Control, Ministry of Health and Welfare, South Korea, No. 1120330
Correspondence to: Dr. Heon Kim, Department of Preventive Medicine and Medical Research Institute, College of Medicine, Chungbuk National University, 52 Naesudong-ro, Hungdok-gu, Cheongju, Chungbuk 361-763, South Korea. kimheon@cbu.ac.kr
Telephone: +82-43-2612864 Fax: +82-43-2742965
Received: April 4, 2013
Revised: July 15, 2013
Accepted: August 4, 2013
Published online: September 21, 2013
Processing time: 169 Days and 20.1 Hours
Core Tip

Core tip: There are few studies addressing the role of the integrin α 1 subunit in the development of gastric cancer. To the best of our knowledge, this study is the first to show that ITGA1 gene single nucleotide polymorphisms and haplotypes are associated with gastric cancer risk.