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World J Gastroenterol. Sep 21, 2013; 19(35): 5828-5836
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5828
Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5828
Aberrant TGF-β1 signaling contributes to the development of primary biliary cirrhosis in murine model
Bin Liu, Jin-Bao Zong, Department of Rheumatology, the Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, Shandong Province, China
Bin Liu, Xuan Zhang, Feng-Chun Zhang, Wen Zhang, Yan Zhao, Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China
Author contributions: Liu B and Zhang X contributed equally to this work; Liu B performed the majority of experiments; Zhang X and Zhang FC designed the study and drafted the manuscript; Zong JB provided analytical tools and revised the manuscript; Zhang W and Zhao Y carried out the data acquisition and analysis; all authors have read and approved the final manuscript.
Supported by Grants from National Key Technology R and D Program in the 11th Five year Plan of China, No. 2008BAI59B03; grants from Emphasis Item Clinical Speciality, Ministry of Health of The People’s Republic of China, 2005
Correspondence to: Feng-Chun Zhang, MD, Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. zhangfccra@yahoo.com.cn
Telephone: +86-10-65295005 Fax: +86-10-65295005
Received: May 1, 2013
Revised: June 24, 2013
Accepted: July 9, 2013
Published online: September 21, 2013
Revised: June 24, 2013
Accepted: July 9, 2013
Published online: September 21, 2013
Core Tip
Core tip: Primary biliary cirrhosis (PBC) is an autoimmune liver disease. Recent studies suggest that transforming growth factor-β1 (TGF-β1) signaling pathway might play an important role in the pathogenesis of PBC. However, whether TGF-β1 signaling pathway is involved in the development of PBC is still unknown. The studies have provided new data of TGF-β1 signaling pathway involving the pathogenesis of PBC, which will pose significant impact on our understanding of the pathogeneses of PBC. TGF-β1 signaling pathway is a potential target for PBC treatment.