Polymorphism in the interleukin-17A promoter contributes to gastric cancer

doi:10.3748/wjg.v19.i34.5693

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Brief Article

World J Gastroenterol. Sep 14, 2013; 19(34): 5693-5699
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5693

Polymorphism in the interleukin-17A promoter contributes to gastric cancer

Alireza Rafiei, Vahid Hosseini, Ghasem Janbabai, Abuzar Ghorbani, Abulghasem Ajami, Touraj Farzmandfar, Maedeh Darzyani Azizi, Jeremy J Gilbreath, D Scott Merrell

Alireza Rafiei, Abuzar Ghorbani, Abulghasem Ajami, Touraj Farzmandfar, Maedeh Darzyani Azizi, Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari 48175-1665, Iran

Vahid Hosseini, Department of Internal Medicine, Imam Hospital, Sari 48175-1665, Iran

Ghasem Janbabai, Hematology and Oncology Ward, Department of Internal Medicine, Imam Hospital, Mazandaran University of Medical Sciences, Sari 48175-1665, Iran

Jeremy J Gilbreath, D Scott Merrell, Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, United States

Author contributions: All the authors contributed to this article.

Supported by The Mazandaran University of Medical Sciences, No. 89-512

Correspondence to: Dr. Vahid Hosseini, Department of Internal Medicine, Imam Hospital, Amir Mazandarani St, Sari 48175-1665, Iran. dr.vahid47@gmail.com

Telephone: +98-151-3543088 Fax: +98-151-3543087

Received: December 5, 2012
Revised: March 25, 2013
Accepted: March 28, 2013
Published online: September 14, 2013
Processing time: 282 Days and 20.9 Hours

Core Tip

Core tip: There is currently a need for genetic markers to identify individuals at risk for developing gastric cancer. In this study, we describe one such marker, a G-197A polymorphism in the interleukin-17A (IL-17A) promoter. Within our study population, individuals who carry the G-197A polymorphism in the IL-17A promoter region may be at a significantly greater risk of developing gastric cancer. Importantly, the presence of this polymorphism alone was sufficient to increase risk of gastric cancer development.