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World J Gastroenterol. Sep 14, 2013; 19(34): 5671-5677
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5671
Published online Sep 14, 2013. doi: 10.3748/wjg.v19.i34.5671
Eviendep® reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouch-anal anastomosis
Carlo Calabrese, Chiara Praticò, Andrea Calafiore, Maurizio Coscia, Lorenzo Gentilini, Gilberto Poggioli, Paolo Gionchetti, Massimo Campieri, Fernando Rizzello, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), University of Bologna, 40138 Bologna, Italy
Author contributions: Calabrese C initiated the study, coordinated the conduct of the whole study, performed the endoscopies; Calabrese C, Praticò C and Calafiore A prepared the draft of the manuscript; Calabrese C and Rizzello F re-evaluated all the endoscopy videos and photos in a blinded manner and scored the images separately; Coscia M, Gentilini L and Poggioli G performed the surgical procedures; Gionchetti P and Campieri M reviewed the manuscript; all authors approved the final version of the manuscript.
Correspondence to: Carlo Calabrese, MD, PhD, DIMEC, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. carlo.calabrese2@unibo.it
Telephone: +39-51-6364191 Fax: +39-51-392538
Received: April 29, 2013
Revised: June 13, 2013
Accepted: July 4, 2013
Published online: September 14, 2013
Processing time: 137 Days and 15.6 Hours
Revised: June 13, 2013
Accepted: July 4, 2013
Published online: September 14, 2013
Processing time: 137 Days and 15.6 Hours
Core Tip
Core tip: Our open study demonstrated for the first time that short-term (90 d) supplementation with Eviendep® in familial adenomatous polyposis patients with ileal pouch-anal anastomosis and with recurrent adenomas in the duodenal mucosa, resulted effective in reducing polyps number of 32% and size of 51%. Eviendep® was easy to manage and its daily use was well tolerated by the patients. Its safety was guaranteed by its composition. Each ingredient is blended into the composition in a lower dose than the one otherwise needed for the single component to similarly exert the desired effect, thus leading to synergistic and/or potentiating effect, with the added advantage of higher safety, even over long-term exposure.