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World J Gastroenterol. Sep 7, 2013; 19(33): 5557-5564
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5557
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5557
Hypermethylation of TGF-β1 gene promoter in gastric cancer
Yong-Qi Wang, Yu-Min Li, School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Yong-Qi Wang, Department of Anesthesiology, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Yu-Min Li, Key Laboratory of Digestive System Tumors, Lanzhou 730030, Gansu Province, China
Yu-Min Li, Tao Liu, Xiao-Kang Liu, Jun-Qiang Zhang, Ju-Wu Guo, Ling-Yun Guo, General Surgery, the Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China
Xun Li, General Surgery, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Liang Qiao, Storr Liver Unit at the Westmead Millennium Institute, the University of Sydney, Sydney, NSW 2145, Australia
Author contributions: Wang YQ and Li YM designed the research; Wang YQ and Guo JW performed the research; Li X performed endoscopy; Liu T performed the histological evaluation; Zhang JQ and Guo LY contributed new reagents and analytical tools; Qiao L and Liu XK analyzed the data; Wang YQ, Li YM and Qiao L wrote the paper.
Supported by The National Natural Science Foundation of China, No. 31270532; the Foundation of Key Laboratory of Digestive System Tumors of Gansu Province and the Fundamental Research Funds for the Central Universities, No. lzujbky-2011-t03-03
Correspondence to: Yu-Min Li, MD, PhD, Professor, School of Life Sciences, Lanzhou University, No. 222 Tianshui South Road, Lanzhou 730000, Gansu Province, China. liym@lzu.edu.cn
Telephone: +86-931-8942744 Fax: +86-931-8942744
Received: March 12, 2013
Revised: June 11, 2013
Accepted: July 18, 2013
Published online: September 7, 2013
Processing time: 181 Days and 9.7 Hours
Revised: June 11, 2013
Accepted: July 18, 2013
Published online: September 7, 2013
Processing time: 181 Days and 9.7 Hours
Core Tip
Core tip:In vitro studies showed that GES-1 cells exposed to Helicobacter pylori (H. pylori) did not show significant transforming growth factor-β1 (TGF-β1) methylation. However, treatment of the GES-1 cells with interleukin (IL)-1β led to a dose-dependent methylation of TGF-β1, which was partially abolished by IL-1RA. The high levels of TGF-β1 promoter methylation in H. pylori positive patients was likely the result of H. pylori-induced inflammation rather than H. pylori itself. IL-1β may be an important mediator for H. pylori-induced gene methylation during gastric cancer development.