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World J Gastroenterol. Sep 7, 2013; 19(33): 5473-5484
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5473
Published online Sep 7, 2013. doi: 10.3748/wjg.v19.i33.5473
Xiaotan Tongfu granules contribute to the prevention of stress ulcers
Bing Yan, Jun Shi, Li-Juan Xiu, Xuan Liu, Yu-Qi Zhou, Shou-Han Feng, Can Lv, Xiu-Xia Yuan, Yin-Cheng Zhang, Yong-Jin Li, Pin-Kang Wei, Zhi-Feng Qin, Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Author contributions: Yan B performed the majority of experiments and wrote the manuscript; Shi J, Xiu LJ, Liu X, Zhou YQ, Feng SH, Lv C, Yuan XX, Zhang YC and Li YJ provided vital reagents; Wei PK provided financial support for this work; Qin ZF designed the study.
Supported by Grants from the Natural Science Foundation of China, No. 2010Z131; and the Excellent Master Training Fund of the Second Military Medical University
Correspondence to: Dr. Zhi-Feng Qin, Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. yanbing3741@gmail.com
Telephone: +86-21-81885471 Fax: +86-21-63520020
Received: May 5, 2013
Revised: June 28, 2013
Accepted: July 17, 2013
Published online: September 7, 2013
Processing time: 127 Days and 5.5 Hours
Revised: June 28, 2013
Accepted: July 17, 2013
Published online: September 7, 2013
Processing time: 127 Days and 5.5 Hours
Core Tip
Core tip: Although the underlying mechanism of stress ulcers is commonly believed to depend on the balance between known aggressive factors and mucosal defense mechanisms, most clinical strategies still aim to inhibit gastric acid. In this study, we demonstrated that the Xiaotan Tongfu granule was similar to ranitidine treatment in reducing gastric lesions in a cold-restraint stress model. The underlying mechanisms may include acceleration of the gastric emptying rate, inhibition of local inflammation, promotion of cell proliferation and suppression of apoptosis. Our study indicated that multiple manipulations of the factors involved in inducing stress ulcers could be as effective as simple acid inhibition.