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World J Gastroenterol. Aug 28, 2013; 19(32): 5295-5301
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5295
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5295
Investigation of genome instability in patients with non-alcoholic steatohepatitis
Hatice Karaman, Department of Pathology, Kayseri Education and Research Hospital, 38030 Kayseri, Turkey
Ahmet Karaman, Department of Gastroenterology, Kayseri Education and Research Hospital, 38030 Kayseri, Turkey
Hamiyet Donmez-Altuntas, Nazmiye Bitgen, Zuhal Hamurcu, Department of Medical Biology, Medical School, Erciyes University, 38030 Kayseri, Turkey
Arzu Oguz, Department of Medical Oncology, Kayseri Education and Research Hospital, 38030 Kayseri, Turkey
Cigdem Karakukcu, Department of Clinical Biochemistry, Kayseri Education and Research Hospital, 38030 Kayseri, Turkey
Author contributions: Karaman H and Karaman A designed the study, collected the data and wrote the manuscript; Donmez-Altuntas H, Bitgen N and Hamurcu Z evaluated the micronucleus assays; and Oguz A and Karakukcu C edited the manuscript.
Correspondence to: Hatice Karaman, MD, Department of Pathology, Kayseri Education and Research Hospital, Alpaslan Mah. Emrah Cad. Beyoğlu Apt. 21/3 Melikgazi, 38030 Kayseri, Turkey. htckaraman@yahoo.com
Telephone: +90-505-2593155 Fax: +90-352-3368857
Received: March 7, 2013
Revised: May 17, 2013
Accepted: June 1, 2013
Published online: August 28, 2013
Revised: May 17, 2013
Accepted: June 1, 2013
Published online: August 28, 2013
Core Tip
Core tip: We aimed to evaluate the micronucleus, nucleoplasmic bridges and nuclear buds in the mitogen-stimulated lymphocytes of patients with non-alcoholic steatohepatitis (NASH). Genomic instability may be a stage in the development of hepatic carcinogenesis. NASH is a major cause of so-called cryptogenic liver cirrhosis and can result in hepatocellular carcinoma (HCC). Our results support this suggestion; although none of the patients had liver cirrhosis in our study, there is high genomic instability in their mitogen-stimulated lymphocytes. Further prospective studies are needed to further clarify this topic, especially among patients with HCC, cirrhosis and NASH.