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World J Gastroenterol. Aug 28, 2013; 19(32): 5261-5270
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5261
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5261
Human development index is associated with mortality-to-incidence ratios of gastrointestinal cancers
Qi-Da Hu, Qi Zhang, Wei Chen, Xue-Li Bai, Ting-Bo Liang, Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Author contributions: Hu QD and Liang TB conceived the study; Hu QD and Zhang Q, Liang TB designed the study; Hu QD collected data; Hu QD, Zhang Q, Chen W and Bai XL analyzed the data; Hu QD, Zhang Q and Chen W drafted the manuscript; Liang TB finalized the manuscript, and took responsibility for the integrity of the data and the accuracy of the data analysis; all authors have read and approved the final manuscript.
Supported by The National Natural Science Funds for Distinguished Young Scholars, No. 30925033; and the Innovation and High-Level Talent Training Program of Department of Health of Zhejiang Province, China
Correspondence to: Ting-Bo Liang, MD, PhD, Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. liangtingbo@zju.edu.cn
Telephone: +86-571-87315006 Fax: +86-571-87315006
Received: May 18, 2013
Revised: July 7, 2013
Accepted: July 17, 2013
Published online: August 28, 2013
Revised: July 7, 2013
Accepted: July 17, 2013
Published online: August 28, 2013
Core Tip
Core tip: This study is the first to explore the exact relationship between the epidemiology of gastrointestinal cancers and area-specific development disparities. We showed the association between the mortality-to-incidence ratios (MIRs) and the human development index at the regional and national levels using a modified “drug dose to inhibition response” model. Further prediction of the MIRs for individual United States states on the basis of best-fitted non-linear models showed little deviation from the actual MIRs in the United States.