Song DS, Bae SH, Song MJ, Lee SW, Kim HY, Lee YJ, Oh JS, Chun HJ, Lee HG, Choi JY, Yoon SK. Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis. World J Gastroenterol 2013; 19(29): 4679-4688 [PMID: 23922465 DOI: 10.3748/wjg.v19.i29.4679]
Corresponding Author of This Article
Si Hyun Bae, MD, PhD, Professor, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul 137-040, South Korea. baesh@catholic.ac.kr
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Aug 7, 2013; 19(29): 4679-4688 Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4679
Hepatic arterial infusion chemotherapy in hepatocellular carcinoma with portal vein tumor thrombosis
Do Seon Song, Si Hyun Bae, Myeong Jun Song, Sung Won Lee, Hee Yeon Kim, Young Joon Lee, Jung Suk Oh, Ho Jong Chun, Hae Giu Lee, Jong Young Choi, Seung Kew Yoon
Do Seon Song, Si Hyun Bae, Myeong Jun Song, Sung Won Lee, Hee Yeon Kim, Jong Young Choi, Seung Kew Yoon, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
Young Joon Lee, Jung Suk Oh, Ho Jong Chun, Hae Giu Lee, Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-040, South Korea
Author contributions: All the authors contributed equally to this manuscript.
Supported by National R and D Program Grant for Cancer Control from the Ministry of Health, Welfare and Family Affairs, Republic of Korea (R0620390-1)
Correspondence to: Si Hyun Bae, MD, PhD, Professor, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul 137-040, South Korea. baesh@catholic.ac.kr
Telephone: +82-2-22582073 Fax: +82-2-34814025
Received: March 29, 2013 Revised: June 2, 2013 Accepted: June 8, 2013 Published online: August 7, 2013 Processing time: 129 Days and 22.8 Hours
Core Tip
Core tip: The aim of this study was to investigate the prognostic factors of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma patients with portal vein tumor thrombosis. The primary findings of this study were as follows: (1) The median survival and time to progression were 7 and 2 mo, respectively; (2) A tumor volume of < 400 cm3 and protein induced by vitamin K absence or antagonist-II were independent pre-treatment prognostic factors; (3) Disease control and ≥ 50% tumor marker reduction were significant prognostic factors after the second cycle of hepatic arterial infusion chemotherapy (HAIC); and (4) Objective tumor response, disease control and portal vein tumor thrombosis response were independent post-treatment prognostic factors at the end of the HAIC.
