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World J Gastroenterol. Jul 21, 2013; 19(27): 4400-4408
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4400
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4400
Transplantation vs resection for hepatocellular carcinoma with compensated liver function after downstaging therapy
Jian-Yong Lei, Lu-Nan Yan, Wen-Tao Wang, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Yan LN is the guarantor and proposed the study; Yan LN and Lei JY performed research and wrote the first draft; Lei JY collected and analyzed the data; All authors contributed to the design and interpretation of the study and to further drafts.
Supported by Grants from The National Sciences and Technology Major Project of China, No. 2012ZX10002-016 and No. 2012ZX10002-017
Correspondence to: Lu-Nan Yan, MD, PhD, Liver Transplantation Center, West China Hospital of Sichuan University, Wuhou District, Chengdu 610041, Sichuan Province, China. yanlunandoctor@163.com
Telephone: +86-28-85422867 Fax: + 86-28-85422867
Received: March 6, 2013
Revised: April 27, 2013
Accepted: June 18, 2013
Published online: July 21, 2013
Processing time: 136 Days and 9.6 Hours
Revised: April 27, 2013
Accepted: June 18, 2013
Published online: July 21, 2013
Processing time: 136 Days and 9.6 Hours
Core Tip
Core tip: We compared advanced-stage hepatocellular carcinoma (HCC) patients who underwent liver transplantation (LT) or liver resection (LR) after successful downstaging therapy, and the recurrence rates and survival outcomes were similar, although the postoperative complication rate was higher for the LT group. The Milan criteria are one of the most strict and accepted criteria for HCC patients to determine eligibility for LT or LR. Therefore, our use of this selection criteria may make this study more ideal than others. Meanwhile, all of our patients accepted successful pre-operative down-staging therapy, the long waiting time can successful avoid the selective bias. So our comparison and results are more credible.