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World J Gastroenterol. Jul 21, 2013; 19(27): 4386-4392
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4386
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4386
Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough
Xiang-Huai Xu, Zhong-Min Yang, Qiang Chen, Li Yu, Si-Wei Liang, Han-Jing Lv, Zhong-Min Qiu, Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China
Author contributions: Xu XH recruited the patients, performed experiments and statistical analysis of data, and wrote the manuscript; Yang ZM, Chen Q, Yu L, Liang SW and Lv HJ took part in the recruitment of patients and review of the manuscript; Qiu ZM designed and coordinated the program, and revised the manuscript.
Supported by National Natural Science Foundation of China, No. 81170079; Shanghai Shenkang Hospital Development Center Project, No. SHDC12012211
Correspondence to: Dr. Zhong-Min Qiu, Department of Respiratory Medicine, Tongji Hospital, Tongji University School of Medicine, No. 389 Xincun Road, Shanghai 200065, China. qiuzhongmin@tongji.edu.cn
Telephone: +86-21-66111286 Fax: +86-21-56050502
Received: February 6, 2013
Revised: May 3, 2013
Accepted: June 5, 2013
Published online: July 21, 2013
Processing time: 164 Days and 23.6 Hours
Revised: May 3, 2013
Accepted: June 5, 2013
Published online: July 21, 2013
Processing time: 164 Days and 23.6 Hours
Core Tip
Core tip: This study evaluated the efficacy and safety of baclofen in a cohort of patients with refractory gastroesophageal reflux-induced chronic cough (GERC) unresponsive to 8 wk of standard anti-reflux therapy consisting of omeprazole twice daily and domperidone. Baclofen is found to be a useful, but suboptimal treatment option for refractory GERC.