Meta-Analysis
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World J Gastroenterol. Jul 14, 2013; 19(26): 4242-4251
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4242
Association of Helicobacter pylori babA2 with peptic ulcer disease and gastric cancer
Mo-Ye Chen, Cai-Yun He, Xue Meng, Yuan Yuan
Mo-Ye Chen, Cai-Yun He, Xue Meng, Yuan Yuan, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Mo-Ye Chen, Cai-Yun He, Xue Meng, Yuan Yuan, Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, Shenyang 110001, Liaoning Province, China
Author contributions: Chen MY and He CY contributed equally to this work; Chen MY and He CY designed the study and performed the data analysis as joint first authors; Chen MY, He CY and Meng X contributed to the discussion and drafted the manuscript; Yuan Y designed the study, contributed to the discussion and edited the manuscript as corresponding author; all authors critically reviewed the manuscript and gave final approval of the version to be published.
Supported by Grants from National Basic Research Program of China, 973 Program Ref No. 2010CB529304; the Grants of the Science and Technology Project of Liaoning province, Ref No. 2011225002; and the Grants of the Science Project of Liaoning Province, Ref [2008]621
Correspondence to: Yuan Yuan, Professor, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. yyuan@mail.cmu.edu.cn
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Received: January 18, 2013
Revised: April 3, 2013
Accepted: May 16, 2013
Published online: July 14, 2013
Core Tip

Core tip: BabA encoded by babA2 gene is an outer member protein of Helicobacter pylori (H. pylori), which plays a key role in facilitating bacterial colonization in the stomach. The association between babA2 and H. pylori-related gastroduodenal diseases is still controversial. We summarized a total of 25 case-control articles with 38 studies in this meta-analysis and evaluated the relationship between babA2 and clinical outcomes. The presence of babA2 may contribute to increased risk of peptic ulcer disease (PUD), especially duodenal ulcer, in western countries. In Asians, babA2 genotype only showed a marginal association with PUD risk, which requires further investigation.