Meta-Analysis
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World J Gastroenterol. Jul 14, 2013; 19(26): 4234-4241
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4234
Hepatitis B or C viral infection and risk of pancreatic cancer: A meta-analysis of observational studies
Jian-Hua Xu, Jin-Jian Fu, Xiao-Li Wang, Jia-Yong Zhu, Xiao-Hua Ye, Si-Dong Chen
Jian-Hua Xu, Jin-Jian Fu, Department of Pathogen Biology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Jian-Hua Xu, Xiao-Li Wang, Xiao-Hua Ye, Si-Dong Chen, Guangdong Key Laboratory of Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong Province, China
Jian-Hua Xu, Jia-Yong Zhu, Institute of Pharmaceutical Bioactive Substances Research, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong Province, China
Jian-Hua Xu, Department of Clinical Laboratory, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, Guangdong Province, China
Jin-Jian Fu, Liuzhou Municipal Maternity and Child Healthcare Hospital, Liuzhou 545001, Guangxi Province, China
Author contributions: Xu JH and Fu JJ contributed equally to this work; Xu JH and Fu JJ designed the study, collected and analyzed the data and wrote the manuscript; Wang XL and Ye XH contributed to the discussion; Zhu JY and Chen SD contributed to the discussion and revised the manuscript.
Supported by International Cooperation Project of the Guangzhou Science and Technology Bureau, No. 2011J5200017; Guangdong Provincial Science and Technology Development Program, No. 2011B031800207
Correspondence to: Dr. Si-Dong Chen, Guangdong Key Laboratory of Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, 280 Waihuan Donglu, Guangzhou Higher Education Mega Center, Guangzhou 510006, Guangdong Province, China. chensidong1@126.com
Telephone: +86-20-39352100 Fax: +86-20-39352100
Received: January 5, 2013
Revised: April 12, 2013
Accepted: May 16, 2013
Published online: July 14, 2013
Processing time: 188 Days and 22.9 Hours
Core Tip

Core tip: Based on the meta-analysis, we identified that chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is associated with pancreatic cancer, especially among Chinese population. Patients with past exposure to HBV/HCV should be screened for hepatocellular carcinoma and other malignancies, especially pancreatic cancer.