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World J Gastroenterol. Jul 14, 2013; 19(26): 4137-4145
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4137
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4137
Effects of rhein on intestinal epithelial tight junction in IgA nephropathy
Sheng-Nan Peng, Ai-Xiang Fu, Xiao-Wen Chen, Graduate School, Medical College of Nanchang University, Nanchang 330006, Jiangxi Province, China
Hui-Hong Zeng, Qing-Xian Zhu, Department of Histology and Embryology, Medical College of Nanchang University, Nanchang 330006, Jiangxi Province, China
Sheng-Nan Peng, Department of Clinical Medicine, Science and Technology School of Jiangxi Traditional Chinese Medicine College, Nanchang 330025, Jiangxi Province, China
Author contributions: Peng SN conceived and designed the research, performed data collection, analysis and interpretation, and drafted the article; Zeng HH revised the article critically for important intellectual content; Fu AX and Chen XW acquired data; Zhu QX conceived and designed the research, and revised the article critically for important intellectual content; all authors have read and approved the final version to be published.
Supported by National Natural Science Foundation of China, No. 81160050; Science and Technology Support Program of China, No. 2008BAI68B01; Science and Technology Support Program of Jiangxi Province, No. 20111BBG70015-3; and Natural Science Foundation of Jiangxi Province, No. 2007GQY0997
Correspondence to: Qing-Xian Zhu, Professor, Department of Histology and Embryology, Medical College of Nanchang University, 461 Ba Yi Avenue, Nanchang 330006, Jiangxi Province, China. qxzzzz2008@163.com
Telephone: +86-791-83969256 Fax: +86-791-83969256
Received: February 28, 2013
Revised: May 22, 2013
Accepted: June 8, 2013
Published online: July 14, 2013
Revised: May 22, 2013
Accepted: June 8, 2013
Published online: July 14, 2013
Core Tip
Core tip: It has been reported that the incidence and aggravation of IgA nephropathy (IgAN) are often accompanied with intestinal mucosal damage. We speculate that various factors cause the destruction of the intestinal mucosal barrier, food proteins activate the mucosal immune system, and a large amount of secretory IgA is deposited in kidney and causes IgAN. Rhubarb has a protective effect on the intestine. Rhein is isolated from rhubarb and we speculate that it also has a protective effect, although this has not been reported to date. We used various biochemical approaches to confirm this.