Brief Article
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World J Gastroenterol. Jul 7, 2013; 19(25): 4066-4071
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.4066
Clinical significance of melatonin concentrations in predicting the severity of acute pancreatitis
Yin Jin, Chun-Jing Lin, Le-Mei Dong, Meng-Jun Chen, Qiong Zhou, Jian-Sheng Wu
Yin Jin, Chun-Jing Lin, Le-Mei Dong, Meng-Jun Chen, Qiong Zhou, Jian-Sheng Wu, Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Author contributions: Wu JS designed the research; Jin Y, Dong LM and Zhou Q performed the research; Lin CJ and Chen MJ provided analytic tools; Jin Y wrote the paper.
Supported by The Wenzhou Municipal Science and Technology Commission Major Projects Funds, No. 20090006
Correspondence to: Jian-Sheng Wu, Professor of Medicine, Department of Gastroenterology, First Affiliated Hospital of Wenzhou Medical College, No. 2 Xuefu Road, Lucheng District, Wenzhou 325000, Zhejiang Province, China. wzwujs@163.com
Telephone: +86-577-55559191 Fax: +86-577-55559192
Received: December 19, 2012
Revised: April 15, 2013
Accepted: June 5, 2013
Published online: July 7, 2013
Processing time: 199 Days and 1.3 Hours
Core Tip

Core tip: It is important to assess the severity and changes in a patient’s condition in a timely and accurate manner. Thus, a comprehensive treatment plan for acute pancreatitis patients is critical. Melatonin plays a protective role in the early course of human acute pancreatitis, and melatonin concentration variations are closely related to the severity of acute pancreatitis and the bedside index for severity in acute pancreatitis score. We can determine the severity of disease in the clinic more objectively, accurately and rapidly by measuring the levels of serum melatonin than by using the standard scoring systems. When the serum concentration of melatonin is below 28.74 ng/L, it is possible that acute pancreatitis patients will develop severe acute pancreatitis.