Differential mucin phenotypes and their significance in a variation of colorectal carcinoma

doi:10.3748/wjg.v19.i25.3957

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 25

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6832)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-4) series.

Item

Count

PDF

405

HTML

3937

Figures (1-4)

145

Tables (1-4)

146

Sum=4633

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

998

Download

1201

Sum=2199

Jul 7, 2013 (publication date) through Apr 28, 2024

Times Cited of This Article

Times Cited (47)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Jul 7, 2013; 19(25): 3957-3968
Published online Jul 7, 2013. doi: 10.3748/wjg.v19.i25.3957

Differential mucin phenotypes and their significance in a variation of colorectal carcinoma

Yasuo Imai, Hidetsugu Yamagishi, Kazunori Fukuda, Yuko Ono, Tohru Inoue, Yoshihiko Ueda

Yasuo Imai, Hidetsugu Yamagishi, Yuko Ono, Yoshihiko Ueda, Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Saitama 343-8555, Japan

Kazunori Fukuda, Joint Research Center, Dokkyo Medical University Koshigaya Hospital, Saitama 343-8555, Japan

Tohru Inoue, Department of Pathology, Tokyo Kosei Nenkin Hospital, Tokyo 162-8543, Japan

Author contributions: Imai Y and Yamagishi H contributed equally to this work; Imai Y designed the study, analyzed the data, and wrote the manuscript; Yamagishi H collected tissue samples along with clinical information; Fukuda K performed immunohistochemistry; Ono Y, Inoue T and Ueda Y contributed to histological analysis.

Supported by Haraguchi Memorial Trust Fund

Correspondence to: Yasuo Imai, MD, Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. ya-imai@dokkyomed.ac.jp

Telephone: +81-48-9658869 Fax: +81-48-9659326

Received: January 5, 2013
Revised: April 20, 2013
Accepted: May 16, 2013
Published online: July 7, 2013

Core Tip

Core tip: Altered mucin expression may be correlated with biological behavior and possibly with the prognosis of colorectal carcinoma (CRC). However, many contradictory results make it difficult to interpret its clinical significance, possibly because of CRC variations. Therefore, we examined mucin (MUC)2 and MUC5AC expressions in different pathological CRC subtypes by immunohistochemistry to determine their true clinical significance. Our results suggest that the expression profiles and the clinical significance of these mucin core proteins are different according to histological subtypes. This may reflect different pathogeneses for these tumors.