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World J Gastroenterol. Jun 28, 2013; 19(24): 3872-3882
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3872
Published online Jun 28, 2013. doi: 10.3748/wjg.v19.i24.3872
Meta-analysis of radiofrequency ablation in combination with transarterial chemoembolization for hepatocellular carcinoma
Jia-Yan Ni, Lin-Feng Xu, Hong-Liang Sun, Yao-Ting Chen, Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510210, Guangdong Province, China
Shan-Shan Liu, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Ni JY and Liu SS performed most of the literature searching and analysis; Sun HL and Chen YT provided vital analytical tools and edited the manuscript; Xu LF provided financial support for this work; Ni JY designed the study and wrote the manuscript.
Correspondence to: Lin-Feng Xu, MD, PhD, Department of Interventional Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiangxi Road, Yuexiu District, Guangzhou 510210, Guangdong Province, China. xu_lin_feng@163.com
Telephone: +86-20-81332269 Fax: +86-20-81332269
Received: December 11, 2012
Revised: March 12, 2013
Accepted: April 3, 2013
Published online: June 28, 2013
Processing time: 198 Days and 9.7 Hours
Revised: March 12, 2013
Accepted: April 3, 2013
Published online: June 28, 2013
Processing time: 198 Days and 9.7 Hours
Core Tip
Core tip: This study aimed to compare the effectiveness and prognosis of combination of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) with that of RFA alone in hepatocellular carcinoma (HCC). To the best of our knowledge, there has been no comprehensive comparison on these two treatments in terms of small-, intermediate- and large-size HCC. Our analysis demonstrated that effectiveness of TACE combined with RFA was better than that of RFA for treatment of intermediate- and large-size HCC. We provide important evidence that TACE-RFA for intermediate- and large-size HCC may be performed more widely in clinical practice.