Meta-Analysis
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World J Gastroenterol. Jun 21, 2013; 19(23): 3678-3684
Published online Jun 21, 2013. doi: 10.3748/wjg.v19.i23.3678
Diagnostic accuracy of endoscopic ultrasound in pancreatic neuroendocrine tumors: A systematic review and meta analysis
Srinivas R Puli, Nikhil Kalva, Matthew L Bechtold, Smitha R Pamulaparthy, Micheal D Cashman, Norman C Estes, Richard H Pearl, Fritz-Henry Volmar, Sonu Dillon, Michael F Shekleton, David Forcione
Srinivas R Puli, Smitha R Pamulaparthy, Micheal D Cashman, Fritz-Henry Volmar, Sonu Dillon, Michael F Shekleton, Division of Gastroenterology and Hepatology, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL 61637, United States
Nikhil Kalva, Department of Internal Medicine, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL 61637, United States
Matthew L Bechtold, Division of Gastroenterology and Hepatology, University of Missouri-Columbia, Columbia, MS 65212, United States
Norman C Estes, Richard H Pearl, Department of Surgery, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, Peoria, IL 61637, United States
David Forcione, Interventional Endoscopy Services, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States
Author contributions: Puli SR, Pamulaparthy SR, Kalva N, Forcione D and Bechtold ML designed research; Puli SR, Bechtold ML, Kalva N and Pamulaparthy SR performed research; Cashman MD, Estes NC, Pearl RH, Volmar FH, Dillon S, Shekleton MF contributed with analytic tools; Puli SR and Forcione D analyzed data; Puli SR, Pamulaparthy SR and Kalva N wrote the paper.
Correspondence to: Srinivas R Puli, MD, Division of Gastroenterology and Hepatology, University of Illinois Peoria Campus, OSF Saint Francis Medical Center, 100 NE Randolph Ave, Peoria, IL 61637, United States. srinivaspuli@yahoo.com
Telephone: +1-309-6249400 Fax: +1-309-6242291
Received: March 2, 2013
Revised: April 6, 2013
Accepted: April 13, 2013
Published online: June 21, 2013
Processing time: 110 Days and 5.6 Hours
Core Tip

Core tip: The published data on the diagnostic accuracy of endoscopic ultrasound (EUS) for detection of pancreatic neuroendocrine tumors is varied. We conducted a comprehensive review of the published literature to assess the diagnostic accuracy of EUS in this setting. Our systematic review and meta-analysis has demonstrated an excellent sensitivity and specificity of EUS in this setting compared to previously published literature of other imaging modalities such as transabdominal ultrasound, computed tomography, and magnetic resonance imaging.