Wu KT, Wang CC, Lu LG, Zhang WD, Zhang FJ, Shi F, Li CX. Hepatocellular carcinoma: Clinical study of long-term survival and choice of treatment modalities. World J Gastroenterol 2013; 19(23): 3649-3657 [PMID: 23801868 DOI: 10.3748/wjg.v19.i23.3649]
Corresponding Author of This Article
Chuan-Xing Li, MD, Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, 651 Dongfeng Road, East, Guangzhou 510060, Guangdong Province, China. lichuanh@mail.sysu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ke-Tong Wu, Wei-Dong Zhang, Fu-Jun Zhang, Feng Shi, Chuan-Xing Li, Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China
Cun-Chuan Wang, the Center of Minimally Invasive Surgery, First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong Province, China
Li-Gong Lu, Cancer Center, Guangdong General Hospital, Guangzhou 510080, Guangdong Province, China
Author contributions: Wu KT, Wang CC and Lu LG contributed equally to this work; Wu KT, Wang CC and Lu LG performed the majority of the study and wrote the manuscript; Zhang WD, Zhang FJ and Shi F were involved in editing the manuscript; Li CX contributed to data acquisition, analysis and interpretation; all authors were involved in revising and approving the final version for publication.
Supported by Guangdong Province Natural Science Fund, No. 10451008901006151
Correspondence to: Chuan-Xing Li, MD, Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, 651 Dongfeng Road, East, Guangzhou 510060, Guangdong Province, China. lichuanh@mail.sysu.edu.cn
Telephone: +86-20-87343272 Fax: +86-20-87343272
Received: January 30, 2013 Revised: March 25, 2013 Accepted: April 9, 2013 Published online: June 21, 2013 Processing time: 141 Days and 18.7 Hours
Core Tip
Core tip: This manuscript was a retrospective analysis and it revealed that the long-term survival of hepatocellular carcinoma (HCC) patients was associated with the number of lesions, liver cirrhosis and Child-Pugh classification, whiletumor diameter, histological stage, and pretreatment level of serum α-fetoprotein were not related. Conditions for long-term survival of HCC patients were: age over 50 years, no cirrhosis, a uninodular lesion, no vessel invasion, tumor-node-metastasis stage I or II, Child-Pugh classification Class A, and appropriate treatment. The best treatment modality for more than 10 years survival compared with 5 years survival were surgery alone > surgery-transcatheter arterial chemoembolization (TACE) > TACE-radiofrequency ablation (RFA) > TACE alone > surgery-TACE-RFA.
