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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 7, 2013; 19(21): 3324-3331
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3324
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3324
Effect of endogenous insulin-like growth factor and stem cell factor on diabetic colonic dysmotility
Yun Wang, Xin-Yu Xu, Yu-Rong Tang, Wei-Wei Yang, Yu-Feng Yuan, Yue-Ji Ning, Yin-Juan Yu, Lin Lin, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Wang Y and Xu XY contributed equally to this study; Wang Y, Xu XY, Ning YJ and Lin L designed research; Wang Y, Xu XY, Tang YR, Yang WW, Yuan YF, Ning YJ, and Yu YJ performed research; Wang Y, Yuan YF and Ning YJ analyzed data; and Wang Y and Lin L wrote the paper.
Supported by The National Natural Science Foundation of China, No. 30971354; The International Cooperation Project of Jiangsu Province Department of Health, No. SBZ201100103; The Graduate Innovation Foundation of Jiangsu Province, China, No. CXZZ11_0704
Correspondence to: Lin Lin, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Gulou District, Nanjing 210029, Jiangsu Province, China. lin9100@yahoo.com.cn
Telephone: +86-25-68136920 Fax: +86-25-83674636
Received: January 30, 2013
Revised: March 23, 2013
Accepted: April 18, 2013
Published online: June 7, 2013
Processing time: 124 Days and 21.5 Hours
Revised: March 23, 2013
Accepted: April 18, 2013
Published online: June 7, 2013
Processing time: 124 Days and 21.5 Hours
Core Tip
Core tip: Endogenous insulin-like growth factor (IGF)-1 levels in diabetic rat colonic tissues were decreased. Hyperglycemia may be involved in initiating this change. In colonic smooth muscle cells, IGF-1 had a direct effect on increasing stem cell factor mRNA and protein levels mediated by extracellular-signal-regulated kinase 1/2 signaling.