Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 7, 2013; 19(21): 3316-3323
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3316
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3316
Differences in HER2 over-expression between proximal and distal gastric cancers in the Chinese population
Xiang-Shan Fan, Jie-Yu Chen, Yi-Fen Zhang, Fan-Qing Meng, Hong-Yan Wu, An-Ning Feng, Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Chang-Feng Li, Department of Statistics, Nanjing University of Finance and Economics, Nanjing 210046, Jiangsu Province, China
Qin Huang, Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Qin Huang, Department of Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System and Harvard Medical School, West Roxbury, MA 02132, United States
Author contributions: Fan XS and Chen JY contributed equally to this work; Fan XS, Chen JY and Huang Q designed the research project; Fan XS, Chen JY, Zhang YF, Meng FQ and Wu HY performed the research; Wu HY performed the immunostaining; Li CF and Feng AN analyzed the data; and Fan XS, Chen JY and Huang Q wrote the paper.
Supported by The National Natural Science Foundation of China, No. 81101815; the Science and Technology Development Project of Medicine in Nanjing, No. YKK08064; Jiangsu Health International Exchange Program and Young Talents Training Project of Health in Nanjing
Correspondence to: Qin Huang, MD, PhD, Department of Pathology and Laboratory Medicine, Veterans Affairs Boston Healthcare System and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, United States. qinhuang0122@gmail.com
Telephone: +1-857-2035020 Fax: +1-857-2035623
Received: January 4, 2013
Revised: February 22, 2013
Accepted: April 9, 2013
Published online: June 7, 2013
Revised: February 22, 2013
Accepted: April 9, 2013
Published online: June 7, 2013
Core Tip
Core tip: In this study, immunostaining of HER2 was performed and scored according to the revised scoring criteria of HercepTestTM used in the ToGA trial in a very large cohort of gastric cancers (GC) patients (957 cases). Our results revealed that HER2 over-expression in GC of Chinese patients was significantly more common in proximal than in distal GC, and was significantly correlated with the Lauren intestinal type and low-grade histology in both proximal and distal GC, and with pM1 disease and male gender in distal GC.