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World J Gastroenterol. Jun 7, 2013; 19(21): 3300-3308
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3300
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3300
Anticancer effects of sweet potato protein on human colorectal cancer cells
Peng-Gao Li, Tai-Hua Mu, Le Deng, Key Laboratory of Agro-products Processing, Ministry of Agriculture, Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Peng-Gao Li, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China
Peng-Gao Li, Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China
Author contributions: Li PG and Mu TH designed the research; Li PG and Deng L carried out the laboratory experiments and analyzed the data; Li PG prepared the manuscript.
Supported by The Earmarked Fund for China Agriculture Research System, No. CARS-11-B-19; “Technique of Processing and Utilization for Plant Proteins” from China-Argentina Science and Technology Cooperation Program, No. 2010DFA32690; Grant from the Capital Medical University, No. 2009ZR03 and No. 2012ZR17; the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions
Correspondence to: Dr. Tai-Hua Mu, Key Laboratory of Agro-products Processing, Ministry of Agriculture, Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China. mutaihuacaas@126.com
Telephone: +86-10-62815541 Fax: +86-10-62815541
Received: December 28, 2012
Revised: March 25, 2013
Accepted: April 27, 2013
Published online: June 7, 2013
Processing time: 158 Days and 2.9 Hours
Revised: March 25, 2013
Accepted: April 27, 2013
Published online: June 7, 2013
Processing time: 158 Days and 2.9 Hours
Core Tip
Core tip: Sweet potato protein (SPP) is a type of serine protease inhibitor that suppresses the activity of trypsin. The current study showed that SPP significantly inhibited proliferation, migration and invasion of human colorectal cancer SW480 cells in vitro. Moreover, the protein significantly suppressed the growth of intraperitoneally xenografted human colorectal cancer HCT-8 cells and volume of bloody ascites formed in nude mice. Spontaneous lung metastasis of a murine lung carcinoma cell line was significantly inhibited by SPP in mice. Notably, both intragastric infusion and intraperitoneal injection of SPP were effective in animal models.