Piekkala M, Hagström J, Tanskanen M, Rintala R, Haglund C, Kolho KL. Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery. World J Gastroenterol 2013; 19(21): 3272-3280 [PMID: 23745029 DOI: 10.3748/wjg.v19.i21.3272]
Corresponding Author of This Article
Maija Piekkala, BMed, Children’s Hospital, University of Helsinki, PO Box 281, FIN-00029 HUS, Helsinki, Finland. maija.piekkala@helsinki.fi
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
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World J Gastroenterol. Jun 7, 2013; 19(21): 3272-3280 Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3272
Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery
Maija Piekkala, Jaana Hagström, Maarit Tanskanen, Risto Rintala, Caj Haglund, Kaija-Leena Kolho
Maija Piekkala, Risto Rintala, Kaija-Leena Kolho, Children’s Hospital, University of Helsinki, FIN-00029 HUS, Helsinki, Finland
Jaana Hagström, Maarit Tanskanen, Department of Pathology, Haartman Institute, University of Helsinki, FIN-00029 HUS, Helsinki, Finland
Caj Haglund, Department of Surgery, Helsinki University Central Hospital, FIN-00029 HUS Helsinki, Finland
Author contributions: Kolho KL, Haglund C and Piekkala M designed the study; Rintala R mainly obtained the biopsies; Hagström J, Piekkala M and Tanskanen M performed the histological analysis of the samples; Piekkala M analyzed the data; Piekkala M wrote the first draft of the manuscript; all authors took part in the critical revision of the paper.
Supported by Päivikki and Sakari Sohlberg Foundation, to Piekkala M; Helsinki University Central Hospital Grant, to Kolho KL; and the Finnish Pediatric Research Foundation, to Kolho KL
Correspondence to: Maija Piekkala, BMed, Children’s Hospital, University of Helsinki, PO Box 281, FIN-00029 HUS, Helsinki, Finland. maija.piekkala@helsinki.fi
Telephone: +358-40-7615172 Fax: +358-9-47186478
Received: November 20, 2012 Revised: April 15, 2013 Accepted: April 18, 2013 Published online: June 7, 2013
Core Tip
Core tip: The risk factors for aggressive pediatric ulcerative colitis (UC) were studied in 24 patients who had undergone surgery by staining diagnostic tissue samples for matrix metalloproteinase-9 and trypsinogen-1 (Tryp-1) and Tryp-2, as well as a trypsin inhibitor. In the UC group, there were significantly more samples that were matrix metalloproteinase-9 positive in comparison to the samples from non-inflammatory bowel disease patients. UC patients undergoing colectomy showed lower immunopositivity of Tryp-1 in the colon epithelium in their diagnostic biopsies when compared to that of conservatively treated patients and non-inflammatory bowel disease patients. The discovery of a low trypsinogen level at diagnosis warrants further study.
