Brief Article
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World J Gastroenterol. Jun 7, 2013; 19(21): 3241-3248
Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3241
Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry
Scott V Adams, Dennis J Ahnen, John A Baron, Peter T Campbell, Steven Gallinger, William M Grady, Loic LeMarchand, Noralane M Lindor, John D Potter, Polly A Newcomb
Scott V Adams, William M Grady, John D Potter, Polly A Newcomb, Cancer Prevention, Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, United States
Dennis J Ahnen, Department of Medicine, Denver VA Medical Center and University of Colorado School of Medicine, Denver, CO 80045, United States
John A Baron, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, United States
Peter T Campbell, Epidemiology Research Program, Department of Intramural Research, American Cancer Society, Atlanta, GA 30303, United States
Steven Gallinger, Division of General Surgery, University of Toronto, Toronto, ON M5G2C4, Canada
Loic LeMarchand, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI 96813, United States
Noralane M Lindor, Department of Health Science Research, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States
Author contributions: Adams SV conceived, designed and performed the analysis, and drafted the manuscript; Ahnen DJ, Baron JA, Campbell PT, Gallinger S, Grady WM, LeMarchand L, Lindor NM, Potter JD and Newcomb PA contributed data and reviewed the results and manuscript.
Supported by The American Society of Preventive Oncology/Prevent Cancer Foundation/American Society for Clinical Oncology Cancer Prevention Research Fellowship to SVA; the Australasian Colorectal Cancer Family Registry, No. U01 CA097735; the Familial Colorectal Neoplasia Collaborative Group, No. U01 CA074799; the Mayo Clinic Cooperative Family Registry for Colon Cancer Studies, No. U01 CA074800; the Ontario Registry for Studies of Familial Colorectal Cancer, No. U01 CA074783; the Seattle Colorectal Cancer Family Registry, No. U01 CA074794; the University of Hawaii Colorectal Cancer Family Registry, No. U01 CA074806; and the University of California, Irvine Informatics Center, No. U01 CA078296
Correspondence to: Scott V Adams, PhD, Cancer Prevention, Public Health Sciences, Fred Hutchinson Cancer Research Center, M3-B232, PO Box 19024, Seattle, WA 98109, United States. sadams@fhcrc.org
Telephone: +1-206-6676427 Fax: +1-206-6675977
Received: December 13, 2012
Revised: March 12, 2013
Accepted: April 3, 2013
Published online: June 7, 2013
Processing time: 173 Days and 11.3 Hours
Core Tip

Core tip: Inflammatory bowel disease (IBD) - and more generally, inflammation - increases risk of colorectal cancer (CRC). Inflammation may also promote cancer progression and metastasis, and therefore, inflammation might be associated with shorter survival with CRC. This study examined whether CRC that occurs in patients with IBD has a worse prognosis than CRC in patients without IBD.