Musio D, De Felice F, Bulzonetti N, Guarnaccia R, Caiazzo R, Bangrazi C, Raffetto N, Tombolini V. Neoadjuvant-intensified treatment for rectal cancer: Time to change? World J Gastroenterol 2013; 19(20): 3052-3061 [PMID: 23716984 DOI: 10.3748/wjg.v19.i20.3052]
Corresponding Author of This Article
Daniela Musio, MD, Department of Radiotherapy, Policlinico Umberto I University of Rome “Sapienza”, Viale Regina Elena 326, 00161 Rome, Italy. daniela.musio@libero.it
Research Domain of This Article
Oncology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 28, 2013; 19(20): 3052-3061 Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3052
Neoadjuvant-intensified treatment for rectal cancer: Time to change?
Daniela Musio, Francesca De Felice, Nadia Bulzonetti, Roberta Guarnaccia, Rossella Caiazzo, Caterina Bangrazi, Nicola Raffetto, Vincenzo Tombolini
Daniela Musio, Francesca De Felice, Nadia Bulzonetti, Roberta Guarnaccia, Rossella Caiazzo, Caterina Bangrazi, Nicola Raffetto, Vincenzo Tombolini, Department of Radiotherapy, Policlinico Umberto I University of Rome “Sapienza”, 00161 Rome, Italy
Author contributions: Musio D and Bulzonetti N designed the study; De Felice F and Guarnaccia R provided data acquisition; De Felice F wrote the manuscript and provided data analysis; Musio D, De Felice F, Bulzonetti N, Caiazzo R and Bangrazi C were involved in the manuscript review; Raffetto N and Tombolini V gave final approval of the version to be published.
Correspondence to: Daniela Musio, MD, Department of Radiotherapy, Policlinico Umberto I University of Rome “Sapienza”, Viale Regina Elena 326, 00161 Rome, Italy. daniela.musio@libero.it
Telephone: +39-6-49973411 Fax: +39-6-49973039
Received: September 10, 2012 Revised: February 19, 2013 Accepted: March 8, 2013 Published online: May 28, 2013 Processing time: 259 Days and 15.3 Hours
Core Tip
Core tip: Management of rectal cancer requires a multimodality treatment approach. The objective of this study was to determine whether neoadjuvant-intensified radiochemotherapy, using traditional radiation therapy in combination with oxaliplatin and 5-fluorouracil (5-FU), could improve the overall and disease-free survival rates in patients with locally advanced rectal cancer. Conventional chemotherapeutic strategies typically only use 5-FU infusion. The results from this study indicate that the addition of oxaliplatin to the chemotherapeutic regime enhances the 5-year overall survival rate, facilitates a high rate of sphincter preservation, and reduces the local recurrence rate relative to the traditional strategies previously reported in the literature. Furthermore, oxaliplatin addition was well tolerated by patients, demonstrating an acceptable level of toxicity.
