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World J Gastroenterol. May 21, 2013; 19(19): 2963-2968
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2963
Published online May 21, 2013. doi: 10.3748/wjg.v19.i19.2963
Effect of Danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions
Zhao-Hui Fang, Yan Liu, Tao-Tao Bao, Ying-Qun Ni, Jian Liu, Guo-Bin Shi, Ji-Ping Wu, Department of Endocrinology, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Hefei 230031, Anhui Province, China
Jun-Ping Yang, Department of Gastroenterology, the People’s Hospital of Taihu Country, Anqing 246404, Anhui Province, China
Hong Zhang, Department of Gastroenterology, Wuhai Mongolian and Traditional Chinese Medicine Hospital, Wuhai 016000, Inner Mongolia Autonomous Region, China
Author contributions: Fang ZH designed the study; Liu Y wrote the manuscript; Bao TT, Ni YQ, Liu J, Shi GB and Wu JP collected the data; Yang JP and Zhang H analyzed the data.
Correspondence to: Zhao-Hui Fang, Director, Department of Endocrinology, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Qingyang South Road No. 1, Hefei 230031, Anhui Province, China. fangzhaohui@medmail.com
Telephone: +86-551-2838605 Fax: +86-551-2838605
Received: December 25, 2012
Revised: February 6, 2013
Accepted: February 28, 2013
Published online: May 21, 2013
Processing time: 146 Days and 5 Hours
Revised: February 6, 2013
Accepted: February 28, 2013
Published online: May 21, 2013
Processing time: 146 Days and 5 Hours
Core Tip
Core tip: The occurrence and development of type 2 diabetes mellitus (T2DM) is accompanied by an inflammatory response. Monocyte chemoattractant protein (MCP)-1 is a member of the CC chemokine subfamily, and is a key mediator of inflammation. MCP-1 also belongs to the chemokine superfamily. T2DM subclinical vascular lesions are a type of mild inflammation. Endothelial cell MCP-1 can be increased markedly. Danzhijiangtang capsule is a traditional Chinese medicine compound preparation. The technique can restrain mononuclear cell chemotactic activity by supplementing qi, nourishing yin and invigorating blood circulation, thereby preventing and treating subclinical vascular lesions.