Ye H, Wang LY, Zhao J, Wang K. Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure. World J Gastroenterol 2013; 19(18): 2818-2825 [PMID: 23687420 DOI: 10.3748/wjg.v19.i18.2818]
Corresponding Author of This Article
Dr. Kai Wang, Department of Hepatology, Qilu Hospital of Shandong University, Wenhuaxi Road 107#, Jinan 250012, Shandong Province, China. wangdoc876@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 14, 2013; 19(18): 2818-2825 Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2818
Increased CD163 expression is associated with acute-on-chronic hepatitis B liver failure
Hong Ye, Li-Yuan Wang, Jing Zhao, Kai Wang
Hong Ye, Li-Yuan Wang, Jing Zhao, Kai Wang, Department of Hepatology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Kai Wang, Institute of Hepatology, Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Ye H and Wang K designed research; Ye H, Wang LY and Zhao J performed research and provided analytic tools; Ye H and Wang LY analyzed data; Ye H and Wang K wrote the paper.
Supported by Grants from Key Project of Chinese Ministry of Science and Technology, No. 2012ZX10002007 and No. 2013ZX10002001; National Natural Science Foundation of China, No. 81171579 and No. 81201287; and Natural Science Foundation of Shandong Province, No. ZR2010HM070 and No. ZR2010HQ040
Correspondence to: Dr. Kai Wang, Department of Hepatology, Qilu Hospital of Shandong University, Wenhuaxi Road 107#, Jinan 250012, Shandong Province, China. wangdoc876@126.com
Telephone: +86-531-82169596 Fax: +86-531-86927544
Received: November 13, 2012 Revised: March 14, 2013 Accepted: March 23, 2013 Published online: May 14, 2013 Processing time: 182 Days and 15.4 Hours
Core Tip
Core tip: This study included three groups, acute-on-chronic hepatitis B liver failure (ACHBLF) patients, chronic hepatitis B (CHB) patients and healthy controls. Flow cytometry was used to analyze the frequency of CD163+ peripheral blood mononuclear cells (PBMCs) and surface protein expression of CD163. Real-time transcription-polymerase chain reaction was performed to assess relative CD163 mRNA levels in PBMCs. The population of CD163+ PBMCs was significantly larger in ACHBLF patients than in CHB patients and healthy controls. CD163 mRNA expression in ACHBLF patients was significantly increased compared with healthy controls. Plasma soluble CD163 (sCD163) levels were markedly increased and correlated with disease severity and prognosis in ACHBLF patients. CD163 and sCD163 may be useful biomarkers for ACHBLF.
