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World J Gastroenterol. May 14, 2013; 19(18): 2811-2817
Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2811
Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2811
Prognostic value of preoperative mean corpuscular volume in esophageal squamous cell carcinoma
Yu-Zhen Zheng, Yong Li, Lan-Jun Zhang, Jian-Hua Fu, Jun-Ye Wang, Department of Thoracic Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong Province, China
Shu-Qin Dai, Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Wei Li, Department of Anesthesia, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Xun Cao, Intensive Care Unit, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Yong Li, Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Author contributions: Zheng YZ and Dai SQ contributed equally to this work; Zheng YZ and Dai SQ drafted the article; Li W revised the manuscript; Cao X and Li Y provided the raw data; Zhang LJ and Fu JH analyzed the data; Wang JY designed the study.
Correspondence to: Jun-Ye Wang, Professor, Department of Thoracic Oncology, Cancer Center, Sun Yat-Sen University, No. 651, Dongfeng Road East, Guangzhou 510060, Guangdong Province, China. zhengyzh@sysucc.org.cn
Telephone: +86-20-87343315 Fax: +86-20-87343268
Received: December 17, 2012
Revised: March 1, 2013
Accepted: March 21, 2013
Published online: May 14, 2013
Processing time: 147 Days and 22.7 Hours
Revised: March 1, 2013
Accepted: March 21, 2013
Published online: May 14, 2013
Processing time: 147 Days and 22.7 Hours
Core Tip
Core tip: Elevated mean corpuscular volume (MCV) has been shown to predict the risk of esophageal squamous cell carcinoma (ESCC). We hypothesized that pretreatment MCV could predict prognosis. In analyzing 298 patients with ESCC, we found that the optimal cut-off for preoperative MCV was 95.6 fl. Multivariate analysis showed that high (> 95.6 fl) preoperative MCV was a negative prognostic factor, along with advanced stage, upper thoracic location and lower preoperative albumin, in patients with ESCC. Median overall survival was significantly longer in patients with low (≤ 95.6 fl) than high preoperative MCV (27.5 mo vs 19.5 mo, P < 0.001).